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2015 ; 8
(9
): 16670-5
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English Wikipedia
Clinical features of ischemic hepatitis caused by shock with four different
types: a retrospective study of 328 cases
#MMPMID26629201
Guo G
; Wu XZ
; Su LJ
; Yang CQ
Int J Clin Exp Med
2015[]; 8
(9
): 16670-5
PMID26629201
show ga
The aim of the study was to investigate the clinical features of ischemic
hepatitis due to shock with four different types (allergic shock, hypovolemic
shock, septic shock, and cardiogenic shock). A total of 328 patients (200 males,
128 females, mean age, 65.84 ± 15.21 years old, range, 15-94 years) diagnosed
with shock in Tongji Hospital were retrospectively investigated from Jun 2008 to
Feb 2010. The parameters of liver function test, including alanine
aminotransferanse (ALT), aspartate aminotransferanse (AST), lactate dehydrogenase
(LDH), total bilirubin (TB), alkaline phosphatase (ALP) and ?-glutamyltransferase
(?-GT), were recorded and analyzed. Besides, the serum levels of C-reactive
protein (CRP) and brain natriuretic peptide (BNP) were also measured and relevant
correlation analysis was conducted. Among all the cases, 242 (73.8%) patients
developed ischemic hepatitis. The mortality of shock patients combined with
ischemic hepatitis was significantly higher than the total mortality (26.0% vs
23.8%, P < 0.05). The incidence of hepatic damage was highest in the septic shock
(87.5%), while the lowest in thehypovolemic shock (49.4%). The sensitivity of ALT
elevation was higher than that of AST. In addition, CRP was positively correlated
with the levels of liver function parameters in the septic shock and BNP was
positively correlated with that in the cardiogenic shock. Ischemic hepatitis is a
common complication of shock, increasing the mortality of shock patients. The
septic shock is the most common cause of hepatic damage in shock patients. CRP
may be a useful predictor for septic shock, while BNP may be a useful predictor
for cardiogenic shock.