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http://scihub22266oqcxt.onion/ C4659087!4659087!26629199     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Exp+Med 2015 ; 8 (9): 16658-63 Nephropedia Template TP {{tp|p=26629199|t=2015. Role of IL-1?, IL-6, IL-8 and IFN-? in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous |pdf=|usr=}}{{26629199}} gab.com Text Role of IL-1 , IL-6, IL-8 and IFN- in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous JO: Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26629199 #FOAvip We discussed the role of IL-1?, IL-6, IL-8 and IFN-? in the pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous (CNS-NPSLE). Serum and cerebrospinal fluid samples were collected from CNS-NPSLE patients, non-CNS SLE patients, patients with intracranial infection and normal subjects. Levels of IL-1?, IL-6, IL-8 and IFN-? in serum and cerebrospinal fluid were detected by ELISA, and the results were compared across the groups. All subjects received cerebral MRI. The risk threshold for each cytokine in CNS-NPSLE group was set as 2.5%. The positive rates of cytokines for different lesions in cerebral MRI findings in CNS-NPSLE group were compared. The correlations between cytokine levels and cerebral MRI findings were analyzed. All groups did not show significant differences in age and gender (F=1.34, P>0.05; x2=2.05, P>0.05); The IL-1?, IL-6, IL-8 and IFN-? levels of serum and cerebrospinal fluid in CNS-NPSLE group were obviously higher than those of the normal control (serum Z14=6.22, 6.04, 6.22, 5.70; cerebrospinal fluid Z14=6.38, 7.10, 6.97, 6.34, P<0.0083); IL-1?, IL-6 and IL-8 levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the non-CNS SLE group (Z12=2.73, Z12=3.18, Z12=3.86; P<0.0083); IL-1?, IL-6, IL-8 and IFN-? levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the serum (Z=3.19, 6.30, 5.44, 3.19, P<0.05); IL-6>20.0679 pg/ml and IL-8>87.1811 pg/ml in the cerebrospinal fluid predicted a higher risk of CNS-NPSLE (x2=11.98, P<0.05; x2=4.65, P<0.05); The positive rates of IL-1? and IL-6 in the cerebrospinal fluid of CNS-NPSLE patients with demyelinating diseases were considerably higher than those of CNS-NPSLE patients with normal MRI findings (x2=10.89, P<0.005; x2=18.47, P<0.005). The positive rates of IL-6 and IFN-? in the cerebrospinal fluid of CNS-NPSLE patients presenting with multiple ischemic foci were significantly higher than those with normal MRI findings (x2=5.56, P<0.005; x2=14.59, P<0.005). Some cytokines are involved in the pathogenesis of CNS-NPSLE and correlated with cerebral MRI findings in CNS-NPSLE. Twit Text FOAVip Role of IL-1 , IL-6, IL-8 and IFN- in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous ????Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26629199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26629199 #FOAvip English Wikipedia <ref>{{Cite pmid|26629199}}</ref> Role of IL-1?, IL-6, IL-8 and IFN-? in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous #MMPMID26629199 Wang JB; Li H; Wang LL; Liang HD; Zhao L; Dong J Int J Clin Exp Med 2015[]; 8 (9): 16658-63 PMID26629199show ga We discussed the role of IL-1?, IL-6, IL-8 and IFN-? in the pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous (CNS-NPSLE). Serum and cerebrospinal fluid samples were collected from CNS-NPSLE patients, non-CNS SLE patients, patients with intracranial infection and normal subjects. Levels of IL-1?, IL-6, IL-8 and IFN-? in serum and cerebrospinal fluid were detected by ELISA, and the results were compared across the groups. All subjects received cerebral MRI. The risk threshold for each cytokine in CNS-NPSLE group was set as 2.5%. The positive rates of cytokines for different lesions in cerebral MRI findings in CNS-NPSLE group were compared. The correlations between cytokine levels and cerebral MRI findings were analyzed. All groups did not show significant differences in age and gender (F=1.34, P>0.05; x2=2.05, P>0.05); The IL-1?, IL-6, IL-8 and IFN-? levels of serum and cerebrospinal fluid in CNS-NPSLE group were obviously higher than those of the normal control (serum Z14=6.22, 6.04, 6.22, 5.70; cerebrospinal fluid Z14=6.38, 7.10, 6.97, 6.34, P<0.0083); IL-1?, IL-6 and IL-8 levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the non-CNS SLE group (Z12=2.73, Z12=3.18, Z12=3.86; P<0.0083); IL-1?, IL-6, IL-8 and IFN-? levels of cerebrospinal fluid of CNS-NPSLE group were higher than those of the serum (Z=3.19, 6.30, 5.44, 3.19, P<0.05); IL-6>20.0679 pg/ml and IL-8>87.1811 pg/ml in the cerebrospinal fluid predicted a higher risk of CNS-NPSLE (x2=11.98, P<0.05; x2=4.65, P<0.05); The positive rates of IL-1? and IL-6 in the cerebrospinal fluid of CNS-NPSLE patients with demyelinating diseases were considerably higher than those of CNS-NPSLE patients with normal MRI findings (x2=10.89, P<0.005; x2=18.47, P<0.005). The positive rates of IL-6 and IFN-? in the cerebrospinal fluid of CNS-NPSLE patients presenting with multiple ischemic foci were significantly higher than those with normal MRI findings (x2=5.56, P<0.005; x2=14.59, P<0.005). Some cytokines are involved in the pathogenesis of CNS-NPSLE and correlated with cerebral MRI findings in CNS-NPSLE. äRole of IL-1?, IL-6, IL-8 and IFN-? in pathogenesis of central nervous(epmc).pdf DeepDyve Pubget Overpricing