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2015 ; 8
(9
): 16658-63
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Role of IL-1?, IL-6, IL-8 and IFN-? in pathogenesis of central nervous system
neuropsychiatric systemic lupus erythematous
#MMPMID26629199
Wang JB
; Li H
; Wang LL
; Liang HD
; Zhao L
; Dong J
Int J Clin Exp Med
2015[]; 8
(9
): 16658-63
PMID26629199
show ga
We discussed the role of IL-1?, IL-6, IL-8 and IFN-? in the pathogenesis of
central nervous system neuropsychiatric systemic lupus erythematous (CNS-NPSLE).
Serum and cerebrospinal fluid samples were collected from CNS-NPSLE patients,
non-CNS SLE patients, patients with intracranial infection and normal subjects.
Levels of IL-1?, IL-6, IL-8 and IFN-? in serum and cerebrospinal fluid were
detected by ELISA, and the results were compared across the groups. All subjects
received cerebral MRI. The risk threshold for each cytokine in CNS-NPSLE group
was set as 2.5%. The positive rates of cytokines for different lesions in
cerebral MRI findings in CNS-NPSLE group were compared. The correlations between
cytokine levels and cerebral MRI findings were analyzed. All groups did not show
significant differences in age and gender (F=1.34, P>0.05; x (2)=2.05, P>0.05);
The IL-1?, IL-6, IL-8 and IFN-? levels of serum and cerebrospinal fluid in
CNS-NPSLE group were obviously higher than those of the normal control (serum Z14
=6.22, 6.04, 6.22, 5.70; cerebrospinal fluid Z14 =6.38, 7.10, 6.97, 6.34,
P<0.0083); IL-1?, IL-6 and IL-8 levels of cerebrospinal fluid of CNS-NPSLE group
were higher than those of the non-CNS SLE group (Z12 =2.73, Z12 =3.18, Z12 =3.86;
P<0.0083); IL-1?, IL-6, IL-8 and IFN-? levels of cerebrospinal fluid of CNS-NPSLE
group were higher than those of the serum (Z=3.19, 6.30, 5.44, 3.19, P<0.05);
IL-6>20.0679 pg/ml and IL-8>87.1811 pg/ml in the cerebrospinal fluid predicted a
higher risk of CNS-NPSLE (x (2)=11.98, P<0.05; x (2)=4.65, P<0.05); The positive
rates of IL-1? and IL-6 in the cerebrospinal fluid of CNS-NPSLE patients with
demyelinating diseases were considerably higher than those of CNS-NPSLE patients
with normal MRI findings (x (2)=10.89, P<0.005; x (2)=18.47, P<0.005). The
positive rates of IL-6 and IFN-? in the cerebrospinal fluid of CNS-NPSLE patients
presenting with multiple ischemic foci were significantly higher than those with
normal MRI findings (x (2)=5.56, P<0.005; x (2)=14.59, P<0.005). Some cytokines
are involved in the pathogenesis of CNS-NPSLE and correlated with cerebral MRI
findings in CNS-NPSLE.
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