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2015 ; 8
(9
): 15766-72
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The protective effect of tadalafil on IMA (ischemia modified albumin) levels in
experimental renal ischemia-reperfusion injury
#MMPMID26629074
Amasyali AS
; Akkurt A
; Kazan E
; Yilmaz M
; Erol B
; Yildiz Y
; Erol H
Int J Clin Exp Med
2015[]; 8
(9
): 15766-72
PMID26629074
show ga
INTRODUCTION: To investigate the effect of the tadalafil in experimental renal
I/R injury and to evaluate these changes with IMA (nonspesific early biomarker of
ischemia), NO and MDA levels. MATERIALS AND METHODS: Twenty four female Wistar
rats were randomly divided into 3 groups (n=8): Group I, sham; Group II, 60 min
I/R; Group III, 60 min I/R plus tadalafil. Tadalafil was administered via an
orogastric tube (10 mg/kg) 24 h prior to the procedure. After ischemia of the
left kidney and 1 h of reperfusion, blood samples were obtained, and the kidney
was removed. RESULTS: Statistically significant histopathologic changes were
exist between groups, with the most severe injury was determined in group II in
comparison to the others (X(2)=21,803, P=0.000). Also mean serum IMA levels were
higher in group II, but not statistically significant (19.83±7.81 U/ml,
22.26±7.14 U/ml and 19.82±7.77 U/ml, P=0.613). In addition, NO values were lower
in I/R groups (P=0.049). There were no differences among the groups in terms of
MDA. CONCLUSIONS: IMA may be used as a nonselective biomarker for IR injury
before the occurrence of necrosis. Decreased IMA levels may indicate the
nephroprotective effect of tadalafil in renal IR injury.