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2015 ; 8
(9
): 14985-91
Nephropedia Template TP
gab.com Text
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English Wikipedia
Curcumin protects against cerebral ischemia-reperfusion injury by activating
JAK2/STAT3 signaling pathway in rats
#MMPMID26628981
Li L
; Li H
; Li M
Int J Clin Exp Med
2015[]; 8
(9
): 14985-91
PMID26628981
show ga
Curcumin (Cur) is the active component in Curcuma longa, and it has been reported
to exhibit a variety of biological effects such as anti-inflammation and
anti-oxidation. This study aims to investigate the effect of Cur on cerebral
ischemia-reperfusion injury and whether the Janus kinase 2 and signal transducer
and activator 3 of transcription (JAK2/STAT3) signaling pathway is involved in
the neuroprotective effects of Cur. Rats were subjected to 2 h transient middle
cerebral artery occlusion (MCAO), followed by 24 h reperfusion. Rats were
randomly assigned into sham group, MCAO group, MCAO + Cur group. AG490, a JAK2
inhibitor, was utilized to throw light upon the underlying mechanism. The results
suggested that compared to MCAO, Cur attenuated neurological deficits, reduced
cerebral infarction area and lowered brain water content. In addition, Cur
reduced the activity of IL-1? and IL-8. The results of western blot indicated
that Cur enhanced the expression of p-JAK2 and p-STAT3, which was abolished by
AG490 administration. Our results suggested that Cur protects effects against
cerebral I/R injury through the activation of JAK2/STAT3 signaling pathway.