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2015 ; 8
(9
): 14577-94
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Puerarin injection for treatment of unstable angina pectoris: a meta-analysis and
systematic review
#MMPMID26628941
Gao Z
; Wei B
; Qian C
Int J Clin Exp Med
2015[]; 8
(9
): 14577-94
PMID26628941
show ga
BACKGROUND: Puerarin is an effective ingredient isolated from Radix Puerariae, a
leguminous plant. In China, a large number of early studies suggest that puerarin
may be used in the treatment of coronary heart disease. In recent years, puerarin
injection has been widely used to treat coronary heart disease and angina
pectoris. OBJECTIVE: To systematically evaluate the clinical efficacy and safety
of puerarin injection in the treatment of unstable angina pectoris (UAP).
METHODS: Data were retrieved from digital databases, including PubMed, Excerpt
Medica Database (EMBASE), China Biology Medicine (CBM), the Cochrane Library, and
Chinese databases. RESULTS: Compared with patients who were treated with
conventional Western medicines alone, the patients who were treated with
conventional Western medicines in combination with puerarin injection exhibited
significant improvements in the incidence of angina pectoris, electrocardiogram
findings, nitroglycerin consumption and plasma endothelin levels. CONCLUSIONS:
Strong evidence suggests that, the use of puerarin in combination with
conventional Western medicines is a better treatment option for treating UAP,
compared with the use of conventional Western medicines alone.