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10.3748/wjg.v21.i44.12519 http://scihub22266oqcxt.onion/10.3748/wjg.v21.i44.12519 C4658608!4658608 !26640330     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26640330 &cmd=llinks): Failed to open stream: HTTP request failed! 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Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease |pdf=|usr=}}{{26640330 }} gab.com Text Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=26640330 #FOAvip The search for biomarkers that characterize specific aspects of inflammatory bowel disease (IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility (or expectancy to be reproducible and translationable into humans) or already measured in humans. A few tests have shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. Twit Text FOAVip Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=26640330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26640330 #FOAvip English Wikipedia <ref>{{Cite pmid|26640330 }}</ref> Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease #MMPMID26640330 Quetglas EG ; Mujagic Z ; Wigge S ; Keszthelyi D ; Wachten S ; Masclee A ; Reinisch W World J Gastroenterol 2015[Nov]; 21 (44 ): 12519-43 PMID26640330 show ga The search for biomarkers that characterize specific aspects of inflammatory bowel disease (IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility (or expectancy to be reproducible and translationable into humans) or already measured in humans. A few tests have shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. |Animals [MESH] |Anti-Inflammatory Agents/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Biotransformation/genetics [MESH] |Diagnostic Imaging/methods [MESH] |Drug Monitoring/*methods [MESH] |Gastrointestinal Agents/adverse effects/pharmacokinetics/*therapeutic use [MESH] |Genetic Markers [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Inflammation Mediators/immunology [MESH] |Inflammatory Bowel Diseases/diagnosis/*drug therapy/genetics/immunology [MESH] |Molecular Diagnostic Techniques [MESH] |Phenotype [MESH] |Predictive Value of Tests [MESH]Update on pathogenesis and predictors of response of therapeutic strat(epmc).pdf DeepDyve Pubget Overpricing