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10.1371/journal.pone.0143423 http://scihub22266oqcxt.onion/10.1371/journal.pone.0143423 C4658161!4658161!26600301     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (11): ä Nephropedia Template TP {{tp|p=26600301|t=2015. Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-?B Signaling |pdf=|usr=}}{{26600301}} gab.com Text Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF- B Signaling JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26600301 #FOAvip SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin ?-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-?B) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulation of these seemingly different roles is coordinated. Here, we show that SHARPIN binds integrin and LUBAC in a mutually exclusive manner. We map the integrin binding site on SHARPIN to the ubiquitin-like (UBL) domain, the same domain implicated in SHARPIN interaction with LUBAC component RNF31 (ring finger protein 31), and identify two SHARPIN residues (V267, L276) required for both integrin and RNF31 regulation. Accordingly, the integrin ?-tail is capable of competing with RNF31 for SHARPIN binding in vitro. Importantly, the full SHARPIN RNF31-binding site contains residues (F263A/I272A) that are dispensable for SHARPIN-integrin interaction. Importantly, disrupting SHARPIN interaction with integrin or RNF31 abolishes SHARPIN-mediated regulation of integrin or NF-?B activity, respectively. Altogether these data suggest that the roles of SHARPIN in inhibiting integrin activity and supporting linear ubiquitination are (molecularly) distinct. Twit Text FOAVip Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF- B Signaling ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26600301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26600301 #FOAvip English Wikipedia <ref>{{Cite pmid|26600301}}</ref> Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-?B Signaling #MMPMID26600301 De Franceschi N; Peuhu E; Parsons M; Rissanen S; Vattulainen I; Salmi M; Ivaska J; Pouwels J PLoS One 2015[]; 10 (11): ä PMID26600301show ga SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin ?-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-?B) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulation of these seemingly different roles is coordinated. Here, we show that SHARPIN binds integrin and LUBAC in a mutually exclusive manner. We map the integrin binding site on SHARPIN to the ubiquitin-like (UBL) domain, the same domain implicated in SHARPIN interaction with LUBAC component RNF31 (ring finger protein 31), and identify two SHARPIN residues (V267, L276) required for both integrin and RNF31 regulation. Accordingly, the integrin ?-tail is capable of competing with RNF31 for SHARPIN binding in vitro. Importantly, the full SHARPIN RNF31-binding site contains residues (F263A/I272A) that are dispensable for SHARPIN-integrin interaction. Importantly, disrupting SHARPIN interaction with integrin or RNF31 abolishes SHARPIN-mediated regulation of integrin or NF-?B activity, respectively. Altogether these data suggest that the roles of SHARPIN in inhibiting integrin activity and supporting linear ubiquitination are (molecularly) distinct. äMutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-?B(epmc).pdf DeepDyve Pubget Overpricing