Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26599209
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(11
): e0142979
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell
Activation via L-Tryptophan and Arginine Depletion and IL-10 Production
#MMPMID26599209
Yue Y
; Huang W
; Liang J
; Guo J
; Ji J
; Yao Y
; Zheng M
; Cai Z
; Lu L
; Wang J
PLoS One
2015[]; 10
(11
): e0142979
PMID26599209
show ga
Interleukin 4-induced gene-1 (IL4I1) was initially described as an early
IL-4-inducible gene in B cells. IL4I1 protein can inhibit T cell proliferation by
releasing its enzymatic catabolite, H2O2, and this effect is associated with
transient down-regulation of T cell CD3 receptor-zeta (TCR?) expression. Herein,
we show that IL4I1 contributes to the regulation of macrophage programming. We
found that expression of IL4I1 increased during bone marrow-derived macrophage
(BMDM) differentiation, expression of IL4I1 is much higher in primary macrophages
than monocytes, and IL4I1 expression in BMDMs could be induced by Th1 and Th2
cytokines in two different patterns. Gene expression analysis revealed that
overexpression of IL4I1 drove the expression of M2 markers (Fizz1, Arg1, YM-1,
MR) and inhibited the expression of M1-associated cytokines. Conversely,
knockdown of IL4I1 by siRNA resulted in opposite effects, and also attenuated
STAT-3 and STAT-6 phosphorylation. Furthermore, IL4I1 produced by macrophages
catalyzed L-tryptophan degradation, while levo-1-methyl-tryptophan (L-1-MT), but
not dextro-1-methyl-tryptophan, partially rescued IL4I1-dependent inhibition of T
cell activation. Other inhibitors, such as diphenylene iodonium (DPI), an
anti-IL-10R? blocking antibody, and a nitric oxide synthase inhibitor,
NG-monomethyl-L-arginine, also had this effect. Overall, our findings indicate
that IL4I1 promotes an enhanced M2 functional phenotype, which is most likely
associated with the phosphorylation of STAT-6 and STAT-3. Moreover, DPI, L-1-MT,
NG-monomethyl-L-arginine, and anti-IL-10R? blocking antibody were all found to be
effective IL4I1 inhibitors in vitro.