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10.1007/s10545-014-9782-8 http://scihub22266oqcxt.onion/10.1007/s10545-014-9782-8 C4657728!4657728!25338511     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Inherit+Metab+Dis 2015 ; 38 (2): 273-7 Nephropedia Template TP {{tp|p=25338511|t=2015. Successive Distinct High-Grade Gliomas in L-2-hydroxyglutaric Aciduria |pdf=|usr=}}{{25338511}} gab.com Text Successive Distinct High-Grade Gliomas in L-2-hydroxyglutaric Aciduria JO: J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=25338511 #FOAvip Patients with L-2-hydroxyglutaric aciduria are at risk for developing cerebral neoplasms, particularly gliomas, as one of the optical isomers of the known oncometabolite, 2-hydroxyglutarate is produced in L-2-hydroxyglutaric aciduria. To illustrate the concept of sustained oncogenic potential in permanent exposure to L-2-hydroxyglutarate in brain tissue, we present the medical history of a patient with L-2-hydroxyglutaric aciduria who underwent surgery to remove a right temporal anaplastic astrocytoma and developed an anatomically distinct, but histopathologically similar, tumor in the left frontal region 40 months later. This is the first reported case of successive distinct gliomas in a patient with L-2-hydroxyglutaric aciduria. While this implies a significant, cumulative lifetime risk for cerebral neoplasms in patients with this rare organic aciduria, it also allows further insight into a unique mechanism of tumorigenesis in the brain. Twit Text FOAVip Successive Distinct High-Grade Gliomas in L-2-hydroxyglutaric Aciduria ????J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=25338511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25338511 #FOAvip English Wikipedia <ref>{{Cite pmid|25338511}}</ref> Successive Distinct High-Grade Gliomas in L-2-hydroxyglutaric Aciduria #MMPMID25338511 Patay Z; Orr BA; Shulkin BL; Hwang SN; Ying Y; Broniscer A; Boop FA; Ellison M.D. DW J Inherit Metab Dis 2015[Mar]; 38 (2): 273-7 PMID25338511show ga Patients with L-2-hydroxyglutaric aciduria are at risk for developing cerebral neoplasms, particularly gliomas, as one of the optical isomers of the known oncometabolite, 2-hydroxyglutarate is produced in L-2-hydroxyglutaric aciduria. To illustrate the concept of sustained oncogenic potential in permanent exposure to L-2-hydroxyglutarate in brain tissue, we present the medical history of a patient with L-2-hydroxyglutaric aciduria who underwent surgery to remove a right temporal anaplastic astrocytoma and developed an anatomically distinct, but histopathologically similar, tumor in the left frontal region 40 months later. This is the first reported case of successive distinct gliomas in a patient with L-2-hydroxyglutaric aciduria. While this implies a significant, cumulative lifetime risk for cerebral neoplasms in patients with this rare organic aciduria, it also allows further insight into a unique mechanism of tumorigenesis in the brain. äSuccessive Distinct High-Grade Gliomas in L-2-hydroxyglutaric Aciduria(epmc).pdf DeepDyve Pubget Overpricing