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10.1038/srep17016 http://scihub22266oqcxt.onion/10.1038/srep17016 C4657060!4657060!26596243     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26596243|t=2015. Kill-painting of hypoxic tumours in charged particle therapy |pdf=|usr=}}{{26596243}} gab.com Text Kill-painting of hypoxic tumours in charged particle therapy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26596243 #FOAvip Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of the oxygen concentration is well described for X-rays. It has also been demonstrated that radioresistance in anoxia is reduced using high-LET radiation rather than conventional X-rays. However, the dependence of the oxygen enhancement ratio (OER) on radiation quality in the regions of intermediate oxygen concentrations, those normally found in tumours, had never been measured and biophysical models were based on extrapolations. Here we present a complete survival dataset of mammalian cells exposed to different ions in oxygen concentration ranging from normoxia (21%) to anoxia (0%). The data were used to generate a model of the dependence of the OER on oxygen concentration and particle energy. The model was implemented in the ion beam treatment planning system to prescribe uniform cell killing across volumes with heterogeneous radiosensitivity. The adaptive treatment plans have been validated in two different accelerator facilities, using a biological phantom where cells can be irradiated simultaneously at three different oxygen concentrations. We thus realized a hypoxia-adapted treatment plan, which will be used for painting by voxel of hypoxic tumours visualized by functional imaging. Twit Text FOAVip Kill-painting of hypoxic tumours in charged particle therapy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26596243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26596243 #FOAvip English Wikipedia <ref>{{Cite pmid|26596243}}</ref> Kill-painting of hypoxic tumours in charged particle therapy #MMPMID26596243 Tinganelli W; Durante M; Hirayama R; Krämer M; Maier A; Kraft-Weyrather W; Furusawa Y; Friedrich T; Scifoni E Sci Rep 2015[]; 5 (ä): ä PMID26596243show ga Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of the oxygen concentration is well described for X-rays. It has also been demonstrated that radioresistance in anoxia is reduced using high-LET radiation rather than conventional X-rays. However, the dependence of the oxygen enhancement ratio (OER) on radiation quality in the regions of intermediate oxygen concentrations, those normally found in tumours, had never been measured and biophysical models were based on extrapolations. Here we present a complete survival dataset of mammalian cells exposed to different ions in oxygen concentration ranging from normoxia (21%) to anoxia (0%). The data were used to generate a model of the dependence of the OER on oxygen concentration and particle energy. The model was implemented in the ion beam treatment planning system to prescribe uniform cell killing across volumes with heterogeneous radiosensitivity. The adaptive treatment plans have been validated in two different accelerator facilities, using a biological phantom where cells can be irradiated simultaneously at three different oxygen concentrations. We thus realized a hypoxia-adapted treatment plan, which will be used for painting by voxel of hypoxic tumours visualized by functional imaging. äKill-painting of hypoxic tumours in charged particle therapy (epmc).pdf DeepDyve Pubget Overpricing