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10.4331/wjbc.v6.i4.358 http://scihub22266oqcxt.onion/10.4331/wjbc.v6.i4.358 C4656912!4656912!26629319     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Biol+Chem 2015 ; 6 (4): 358-65 Nephropedia Template TP {{tp|p=26629319|t=2015. Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function |pdf=|usr=}}{{26629319}} gab.com Text Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function JO: World J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26629319 #FOAvip Caldecrin was originally isolated from the pancreas as a factor that reduced serum calcium levels. This secreted serine protease has chymotrypsin-like activity and is also known as chymotrypsin C; it belongs to the elastase family. Although intravenous administration of caldecrin decreases the serum calcium concentration even when its protease activity is blocked, this effect does require cleavage of caldecrin?s pro-peptide by trypsin, converting it to the mature enzyme. Ectopic intramuscular expression of caldecrin prevented bone resorption in ovariectomized mice. Caldecrin inhibited parathyroid hormone-stimulated calcium release from fetal mouse long bone organ cultures. Furthermore, caldecrin suppressed the formation of osteoclasts from bone marrow cells by inhibiting the receptor activator of nuclear factor-? B ligand (RANKL)-stimulated phospholipase C?-calcium oscillation-calcineurin-nuclear factor of activated T-cells, cytoplasmic 1 pathway. Caldecrin also suppressed the bone resorption activity of mature osteoclasts by preventing RANKL-stimulated Src activation, calcium entry, and actin ring formation. In vivo and in vitro studies have indicated that caldecrin is a unique multifunctional protease with anti-osteoclastogenic activities that are distinct from its protease activity. Caldecrin might be a potential therapeutic target for the treatment of osteolytic diseases such as osteoporosis and osteoarthritis. This mini-review describes caldecrin?s historical background and its mechanisms of action. Twit Text FOAVip Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function ????World J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26629319 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26629319 #FOAvip English Wikipedia <ref>{{Cite pmid|26629319}}</ref> Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function #MMPMID26629319 Tomomura M; Tomomura A World J Biol Chem 2015[Nov]; 6 (4): 358-65 PMID26629319show ga Caldecrin was originally isolated from the pancreas as a factor that reduced serum calcium levels. This secreted serine protease has chymotrypsin-like activity and is also known as chymotrypsin C; it belongs to the elastase family. Although intravenous administration of caldecrin decreases the serum calcium concentration even when its protease activity is blocked, this effect does require cleavage of caldecrin?s pro-peptide by trypsin, converting it to the mature enzyme. Ectopic intramuscular expression of caldecrin prevented bone resorption in ovariectomized mice. Caldecrin inhibited parathyroid hormone-stimulated calcium release from fetal mouse long bone organ cultures. Furthermore, caldecrin suppressed the formation of osteoclasts from bone marrow cells by inhibiting the receptor activator of nuclear factor-? B ligand (RANKL)-stimulated phospholipase C?-calcium oscillation-calcineurin-nuclear factor of activated T-cells, cytoplasmic 1 pathway. Caldecrin also suppressed the bone resorption activity of mature osteoclasts by preventing RANKL-stimulated Src activation, calcium entry, and actin ring formation. In vivo and in vitro studies have indicated that caldecrin is a unique multifunctional protease with anti-osteoclastogenic activities that are distinct from its protease activity. Caldecrin might be a potential therapeutic target for the treatment of osteolytic diseases such as osteoporosis and osteoarthritis. This mini-review describes caldecrin?s historical background and its mechanisms of action. äCaldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclas(epmc).pdf DeepDyve Pubget Overpricing