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http://scihub22266oqcxt.onion/ C4656762!4656762!26692929     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2015 ; 7 (10): 1850-9 Nephropedia Template TP {{tp|p=26692929|t=2015. PGC-1 mediates the regulation of metformin in muscle irisin expression and function |pdf=|usr=}}{{26692929}} gab.com Text PGC-1 mediates the regulation of metformin in muscle irisin expression and function JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=26692929 #FOAvip Background: Overweight and obesity are rapidly becoming major global health, social, and economic problems. Irisin is a newly termed hormone that is related to metabolic diseases. In the present study, the mechanism underlying the effect of Metformin on promoting irisin release from skeletal muscle was investigated. Methods: C57BL/6J-ob/ob was orally administrated with Metformin for 4 weeks. The plasma irisin, insulin, and glucose were detected. Mouse skeletal muscle myoblasts C2C12 cells were treated with Metformin for 24 h. The molecules PGC-1?, FNDC5, AMPK, and ERK mRNA/proteins were quantified by real-time PCR and western blotting in vivo and in vitro. Results: Metformin elevated FNDC5 mRNA/protein expression of skeletal muscle and plasma irisin concentration in ob/ob mice. PGC-1?, p-AMPK and p-ERK protein expression was up-regulated by Metformin in skeletal muscle and C2C12 cells. In addition, the decrease in irisin concentration and protein expression of FNDC5, p-AMPK, and p-ERK induced by siRNA-PGC-1? could not be reversed by Metformin. Conclusion: Our study demonstrates that Metformin stimulates irisin secretion from skeletal muscle into the circulation system of obese mice, and that PGC-1? is a critical regulator in this process. Twit Text FOAVip PGC-1 mediates the regulation of metformin in muscle irisin expression and function ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=26692929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26692929 #FOAvip English Wikipedia <ref>{{Cite pmid|26692929}}</ref> PGC-1 mediates the regulation of metformin in muscle irisin expression and function #MMPMID26692929 Yang Z; Chen X; Chen Y; Zhao Q Am J Transl Res 2015[]; 7 (10): 1850-9 PMID26692929show ga Background: Overweight and obesity are rapidly becoming major global health, social, and economic problems. Irisin is a newly termed hormone that is related to metabolic diseases. In the present study, the mechanism underlying the effect of Metformin on promoting irisin release from skeletal muscle was investigated. Methods: C57BL/6J-ob/ob was orally administrated with Metformin for 4 weeks. The plasma irisin, insulin, and glucose were detected. Mouse skeletal muscle myoblasts C2C12 cells were treated with Metformin for 24 h. The molecules PGC-1?, FNDC5, AMPK, and ERK mRNA/proteins were quantified by real-time PCR and western blotting in vivo and in vitro. Results: Metformin elevated FNDC5 mRNA/protein expression of skeletal muscle and plasma irisin concentration in ob/ob mice. PGC-1?, p-AMPK and p-ERK protein expression was up-regulated by Metformin in skeletal muscle and C2C12 cells. In addition, the decrease in irisin concentration and protein expression of FNDC5, p-AMPK, and p-ERK induced by siRNA-PGC-1? could not be reversed by Metformin. Conclusion: Our study demonstrates that Metformin stimulates irisin secretion from skeletal muscle into the circulation system of obese mice, and that PGC-1? is a critical regulator in this process. äPGC-1 mediates the regulation of metformin in muscle irisin expression(epmc).pdf DeepDyve Pubget Overpricing