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10.1007/s00428-015-1824-6 http://scihub22266oqcxt.onion/10.1007/s00428-015-1824-6 C4656713!4656713!26369547     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virchows+Arch 2015 ; 467 (5): 583-93 Nephropedia Template TP {{tp|p=26369547|t=2015. Old dilemma: asthma with irreversible airway obstruction or COPD |pdf=|usr=}}{{26369547}} gab.com Text Old dilemma: asthma with irreversible airway obstruction or COPD JO: Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=26369547 #FOAvip Older asthmatic patients may develop fixed airway obstruction and clinical signs of chronic obstructive pulmonary disease (COPD). We investigated the added value of pathological evaluation of bronchial biopsies to help differentiate asthma from COPD, taking into account smoking, age, and inhaled corticosteroid (ICS) use. Asthma and COPD patients (24 of each category) were matched for ICS use, age, FEV1, and smoking habits. Five pulmonary and five general pathologists examined bronchial biopsies using an interactive website, without knowing patient information. They were asked to diagnose asthma or COPD on biopsy findings in both a pairwise and randomly mixed order of cases during four different phases, with intervals of 4?6 weeks, covering a maximal period of 36 weeks. Clinically concordant diagnoses of asthma or COPD varied between 63 %-73 %, without important differences between pairwise vs randomly mixed examination or between general vs pulmonary pathologists. The highest percentage of concordant diagnoses was in young asthmatic patients without ICS use and in COPD patients with ICS use. In non ICS users with fixed airway obstruction, a COPD diagnosis was favored if abnormal presence of glands, squamous metaplasia, and submucosal infiltrate was present and an asthma diagnosis in case of abnormal presence of goblet cells. In ICS users with fixed airway obstruction, abnormal presence of submucosal infiltrates, basement membrane thickening, eosinophils, and glands was associated with asthma. Histological characteristics in bronchial biopsies are reproducibly recognized by pathologists, yet the differentiation by histopathology between asthma and COPD is difficult without information about ICS use.Electronic supplementary material: The online version of this article (doi:10.1007/s00428-015-1824-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Old dilemma: asthma with irreversible airway obstruction or COPD ????Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=26369547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26369547 #FOAvip English Wikipedia <ref>{{Cite pmid|26369547}}</ref> Old dilemma: asthma with irreversible airway obstruction or COPD #MMPMID26369547 Fattahi F; Vonk JM; Bulkmans N; Fleischeuer R; Gouw A; Grünberg K; Mauad T; Popper H; Felipe-Silva A; Vrugt B; Wright JL; Yang HM; Kocks JW; Hylkema MN; Postma DS; Timens W; ten Hacken NHT Virchows Arch 2015[]; 467 (5): 583-93 PMID26369547show ga Older asthmatic patients may develop fixed airway obstruction and clinical signs of chronic obstructive pulmonary disease (COPD). We investigated the added value of pathological evaluation of bronchial biopsies to help differentiate asthma from COPD, taking into account smoking, age, and inhaled corticosteroid (ICS) use. Asthma and COPD patients (24 of each category) were matched for ICS use, age, FEV1, and smoking habits. Five pulmonary and five general pathologists examined bronchial biopsies using an interactive website, without knowing patient information. They were asked to diagnose asthma or COPD on biopsy findings in both a pairwise and randomly mixed order of cases during four different phases, with intervals of 4?6 weeks, covering a maximal period of 36 weeks. Clinically concordant diagnoses of asthma or COPD varied between 63 %-73 %, without important differences between pairwise vs randomly mixed examination or between general vs pulmonary pathologists. The highest percentage of concordant diagnoses was in young asthmatic patients without ICS use and in COPD patients with ICS use. In non ICS users with fixed airway obstruction, a COPD diagnosis was favored if abnormal presence of glands, squamous metaplasia, and submucosal infiltrate was present and an asthma diagnosis in case of abnormal presence of goblet cells. In ICS users with fixed airway obstruction, abnormal presence of submucosal infiltrates, basement membrane thickening, eosinophils, and glands was associated with asthma. Histological characteristics in bronchial biopsies are reproducibly recognized by pathologists, yet the differentiation by histopathology between asthma and COPD is difficult without information about ICS use.Electronic supplementary material: The online version of this article (doi:10.1007/s00428-015-1824-6) contains supplementary material, which is available to authorized users. äOld dilemma: asthma with irreversible airway obstruction or COPD (epmc).pdf DeepDyve Pubget Overpricing