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TGF-?1 expression and angiogenesis in colorectal cancer tissue #MMPMID12046078
Xiong B; Gong LL; Zhang F; Hu MB; Yuan HY
World J Gastroenterol 2002[Jun]; 8 (3): 496-8 PMID12046078show ga
AIM: Transforming growth factor (TGF) ?1 is involved in a variety of important cellular functions, including cell growth and differentiation, angiogenesis, immune function and extracellular matrix formation. However, the role of TGF-?1 as an angiogenic factor in colorectal cancer is still unclear. We investigate the relationship between transforming growth factor ?1 and angiogenesis by analyzing the expression of transforming growth factor (TGF) ?1 in colorectal cancer, as well as its association with VEGF and MVD.METHODS: The expression of TGF-?1, VEGF, as well as MVD were detected in 98 colorectal cancer by immunohistochemical staining. The relationship between the TGF-?1 expression and VEGF expression, MVD was evaluated. To evaluate the effect of TGF-?1 on the angiogenesis of colorectal cancers.RESULTS: Among 98 cases of colorectal cancer, 37 were positive for TGF-?1 (37.8%), 36 for VEGF (36.7%), respectively. The microvessel counts ranged from 19 to 139.8, with a mean of 48.7 (standard deviation, 21.8). The expression of TGF-?1 was correlated significantly with the depth of invasion, stage of disease, lymph node metastasis, VEGF expression and MVD. Patients in T3-T4, stage III-IV and with lymph node metastasis had much higher expression of TGF-?1 than patients in T1-T2, stageI-II and without lymph node metastasis (P < 0.05). The positive expression rate of VEGF (58.3%) in the TGF-?1 positive group is higher than that in the TGF-?1 negative group (41.7%, P < 0.05). Also, the microvessel count (54 ± 18) in TGF-?1 positive group is significantly higher than that in TGF-?1 negative group (46 ± 15, P < 0.05). The microvessel count in tumors with both TGF-?1 and VEGF positive were the highest (58 ± 20, 36-140, P < 0.05). Whereas that in tumors with both TGF-?1 and VEGF negative were the lowest (38 ± 16, 19-60, P < 0.05).CONCLUSION: TGF-?1 might be associated with tumor progression by madulating the angiogenesis in colorectal cancer and TGF-?1 may be used as a possible biomarker.
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World+J+Gastroenterol 2002 ; 8 (3): 496-8
