Hypoxia-inducible factor-1 in tumour angiogenesis #MMPMID15069703
Shi YH; Fang WG
World J Gastroenterol 2004[Apr]; 10 (8): 1082-7 PMID15069703show ga
Hypoxia-inducible factor-1 (HIF-1), composed of HIF-? and HIF-? subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1? is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic adaptation to low oxygen and promotes survival. HIF-1 is critical for both physiological and pathological processes. Several dozens of putative direct HIF-1 target genes have been identified on the basis of one or more cis-acting hypoxia-response elements that contain an HIF-1 binding site. A variety of regulators including growth factors, genetic alterations, stress activators, and some carcinogens have been documented for regulation of HIF-1 in which several signaling pathways are involved depending on the stimuli and cell types. Activation of HIF-1 in combination with activated signaling pathways and regulators is implicated in tumour progression and prognosis. This review presents a summary of the structure and function of HIF-1?, and correlation among specific regulators and their signaling pathways.
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World+J+Gastroenterol 2004 ; 10 (8): 1082-7
