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10.1016/j.bbamcr.2014.03.028 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2014.03.028 C4655877!4655877 !24721172     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24721172 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2014 ; 1843 (7 ): 1365-72 Nephropedia Template TP {{tp|p=24721172 |t=2014. Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK? |pdf=|usr=}}{{24721172 }} gab.com Text Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24721172 #FOAvip Stringent negative regulation of the transcription factor NF-?B is essential for maintaining cellular stress responses and homeostasis. However, the tight regulation mechanisms of IKK? are still not clear. Here, we reported that nemo-like kinase (NLK) is a suppressor of tumor necrosis factor (TNF?)-induced NF-?B signaling by inhibiting the phosphorylation of IKK?. Overexpression of NLK largely blocked TNF?-induced NF-?B activation, p65 nuclear localization and I?B? degradation; whereas genetic inactivation of NLK showed opposing results. Mechanistically, we identified that NLK interacted with I?B kinase (IKK)-associated complex, which in turn inhibited the assembly of the TAK1/IKK? and thereby, diminished the I?B kinase phosphorylation. Our results indicate that NLK functions as a pivotal negative regulator in TNF?-induced activation of NF-?B via disrupting the interaction of TAK1 with IKK?. Twit Text FOAVip Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24721172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24721172 #FOAvip English Wikipedia <ref>{{Cite pmid|24721172 }}</ref> Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK? #MMPMID24721172 Li SZ ; Zhang HH ; Liang JB ; Song Y ; Jin BX ; Xing NN ; Fan GC ; Du RL ; Zhang XD Biochim Biophys Acta 2014[Jul]; 1843 (7 ): 1365-72 PMID24721172 show ga Stringent negative regulation of the transcription factor NF-?B is essential for maintaining cellular stress responses and homeostasis. However, the tight regulation mechanisms of IKK? are still not clear. Here, we reported that nemo-like kinase (NLK) is a suppressor of tumor necrosis factor (TNF?)-induced NF-?B signaling by inhibiting the phosphorylation of IKK?. Overexpression of NLK largely blocked TNF?-induced NF-?B activation, p65 nuclear localization and I?B? degradation; whereas genetic inactivation of NLK showed opposing results. Mechanistically, we identified that NLK interacted with I?B kinase (IKK)-associated complex, which in turn inhibited the assembly of the TAK1/IKK? and thereby, diminished the I?B kinase phosphorylation. Our results indicate that NLK functions as a pivotal negative regulator in TNF?-induced activation of NF-?B via disrupting the interaction of TAK1 with IKK?. |Cell Nucleus/drug effects/metabolism [MESH] |Gene Expression Regulation [MESH] |HCT116 Cells [MESH] |HEK293 Cells [MESH] |Humans [MESH] |I-kappa B Kinase/genetics/*metabolism [MESH] |Intracellular Signaling Peptides and Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |MAP Kinase Kinase Kinases/genetics/*metabolism [MESH] |NF-kappa B/genetics/*metabolism [MESH] |Phosphorylation/drug effects [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/antagonists & inhibitors/genetics/*metabolism [MESH] |Proteolysis [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Signal Transduction [MESH]Nemo-like kinase (NLK) negatively regulates NF-kappa B activity throug(epmc).pdf DeepDyve Pubget Overpricing