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10.1016/j.cell.2015.10.067

http://scihub22266oqcxt.onion/10.1016/j.cell.2015.10.067
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C4655822!4655822!26590417
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suck abstract from ncbi


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pmid26590417      Cell 2015 ; 163 (5): 1064-78
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  • Establishment and Dysfunction of the Blood-Brain Barrier #MMPMID26590417
  • Zhao Z; Nelson AR; Betsholtz C; Zlokovic BV
  • Cell 2015[Nov]; 163 (5): 1064-78 PMID26590417show ga
  • Structural and functional brain connectivity, synaptic activity and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases including Alzheimer?s disease.
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