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10.1073/pnas.1519633112 http://scihub22266oqcxt.onion/10.1073/pnas.1519633112 C4655570!4655570!26540730     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (46): 14248-53 Nephropedia Template TP {{tp|p=26540730|t=2015. On artifacts in single-molecule force spectroscopy |pdf=|usr=}}{{26540730}} gab.com Text On artifacts in single-molecule force spectroscopy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26540730 #FOAvip The response of single molecules to applied forces can be probed using atomic force microscopes and laser tweezers. In these experiments, a biomolecule is attached, for example, to a mesoscopic (approximately micron size) bead that is trapped in the focus of a laser, via a long intervening polymer. To interpret such experiments, one must know the extent that the measured data reflect the behavior of the molecule of interest. Here, we develop an analytically tractable theory that can be used to determine the influence of the pulling device (apparatus) on the measured quantities, such as the rates of conformational changes. Our theory allows one to make the appropriate corrections when necessary. Twit Text FOAVip On artifacts in single-molecule force spectroscopy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26540730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26540730 #FOAvip English Wikipedia <ref>{{Cite pmid|26540730}}</ref> On artifacts in single-molecule force spectroscopy #MMPMID26540730 Cossio P; Hummer G; Szabo A Proc Natl Acad Sci U S A 2015[Nov]; 112 (46): 14248-53 PMID26540730show ga The response of single molecules to applied forces can be probed using atomic force microscopes and laser tweezers. In these experiments, a biomolecule is attached, for example, to a mesoscopic (approximately micron size) bead that is trapped in the focus of a laser, via a long intervening polymer. To interpret such experiments, one must know the extent that the measured data reflect the behavior of the molecule of interest. Here, we develop an analytically tractable theory that can be used to determine the influence of the pulling device (apparatus) on the measured quantities, such as the rates of conformational changes. Our theory allows one to make the appropriate corrections when necessary. äOn artifacts in single-molecule force spectroscopy (epmc).pdf DeepDyve Pubget Overpricing