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2015 ; 112
(46
): 14266-71
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gab.com Text
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Electron cryotomography reveals ultrastructure alterations in platelets from
patients with ovarian cancer
#MMPMID26578771
Wang R
; Stone RL
; Kaelber JT
; Rochat RH
; Nick AM
; Vijayan KV
; Afshar-Kharghan V
; Schmid MF
; Dong JF
; Sood AK
; Chiu W
Proc Natl Acad Sci U S A
2015[Nov]; 112
(46
): 14266-71
PMID26578771
show ga
Thrombocytosis and platelet hyperreactivity are known to be associated with
malignancy; however, there have been no ultrastructure studies of platelets from
patients with ovarian cancer. Here, we used electron cryotomography (cryo-ET) to
examine frozen-hydrated platelets from patients with invasive ovarian cancer (n =
12) and control subjects either with benign adnexal mass (n = 5) or free from
disease (n = 6). Qualitative inspections of the tomograms indicate significant
morphological differences between the cancer and control platelets, including
disruption of the microtubule marginal band. Quantitative analysis of subcellular
features in 120 platelet electron tomograms from these two groups showed
statistically significant differences in mitochondria, as well as microtubules.
These structural variations in the platelets from the patients with cancer may be
correlated with the altered platelet functions associated with malignancy.
Cryo-ET of platelets shows potential as a noninvasive biomarker technology for
ovarian cancer and other platelet-related diseases.