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10.1073/pnas.1511377112 http://scihub22266oqcxt.onion/10.1073/pnas.1511377112 C4655558!4655558!26578794     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (46): E6339-48 Nephropedia Template TP {{tp|p=26578794|t=2015. Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth |pdf=|usr=}}{{26578794}} gab.com Text Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26578794 #FOAvip Regulators of chromatin structure play critical roles in DNA-based processes. Lysine (K) Methyltransferase 1 (KMT1) homologs perform methylation of H3 lysine-9 and are best known for their essential role in heterochromatin formation and transcriptional silencing. Heterochromatin formation is also important for maintenance of genome stability, although the mechanisms are not well understood. We report that altered activity of Polycomb repressive complex-2 (PRC2), a histone lysine-27 methyltransferase complex, is responsible for genotoxic stress, poor growth, and defective development in KMT1-deficient mutants of Neurospora crassa. Mammalian KMT1 and PRC2 are required for development and are frequently mutated in cancer. This work provides information about the cellular consequences of KMT1 and PRC2 deficiency and provides insights into the regulatory and functional relationships of these conserved enzymes. Twit Text FOAVip Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26578794 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26578794 #FOAvip English Wikipedia <ref>{{Cite pmid|26578794}}</ref> Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth #MMPMID26578794 Basenko EY; Sasaki T; Ji L; Prybol CJ; Burckhardt RM; Schmitz RJ; Lewis ZA Proc Natl Acad Sci U S A 2015[Nov]; 112 (46): E6339-48 PMID26578794show ga Regulators of chromatin structure play critical roles in DNA-based processes. Lysine (K) Methyltransferase 1 (KMT1) homologs perform methylation of H3 lysine-9 and are best known for their essential role in heterochromatin formation and transcriptional silencing. Heterochromatin formation is also important for maintenance of genome stability, although the mechanisms are not well understood. We report that altered activity of Polycomb repressive complex-2 (PRC2), a histone lysine-27 methyltransferase complex, is responsible for genotoxic stress, poor growth, and defective development in KMT1-deficient mutants of Neurospora crassa. Mammalian KMT1 and PRC2 are required for development and are frequently mutated in cancer. This work provides information about the cellular consequences of KMT1 and PRC2 deficiency and provides insights into the regulatory and functional relationships of these conserved enzymes. äGenome-wide redistribution of H3K27me3 is linked to genotoxic stress a(epmc).pdf DeepDyve Pubget Overpricing