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The human hippocampus contributes to both the recollection and familiarity
components of recognition memory
#MMPMID26578784
Merkow MB
; Burke JF
; Kahana MJ
Proc Natl Acad Sci U S A
2015[Nov]; 112
(46
): 14378-83
PMID26578784
show ga
Despite a substantial body of work comprising theoretical modeling, the effects
of medial temporal lobe lesions, and electrophysiological signal analysis, the
role of the hippocampus in recognition memory remains controversial. In
particular, it is not known whether the hippocampus exclusively supports
recollection or both recollection and familiarity--the two latent cognitive
processes theorized to underlie recognition memory. We studied recognition memory
in a large group of patients undergoing intracranial electroencephalographic
(iEEG) monitoring for epilepsy. By measuring high-frequency activity (HFA)--a
signal associated with precise spatiotemporal properties--we show that
hippocampal activity during recognition predicted recognition memory performance
and tracked both recollection and familiarity. Through the lens of dual-process
models, these results indicate that the hippocampus supports both the
recollection and familiarity processes.
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