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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (46): E6284-92 Nephropedia Template TP
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Temperature compensation and temperature sensation in the circadian clock #MMPMID26578788
Kidd PB; Young MW; Siggia ED
Proc Natl Acad Sci U S A 2015[Nov]; 112 (46): E6284-92 PMID26578788show ga
Circadian clocks in animals, plants, and fungi possess the remarkable property of temperature compensation: the clock has a temperature-insensitive period, while retaining the ability to synchronize to temperature cycles. The conservation of temperature compensation across clades means it is likely critical to the function of circadian clocks. Temperature compensation also places the circadian clock in contrast to other biological pathways, which generally have temperature-sensitive time scales. However, the mechanism of temperature compensation remains unknown. We present a general scheme by which a circadian oscillator can be temperature-compensated while still synchronizing to environmental temperature cycles. In particular, we give experimental evidence that the circadian clock consists of a temperature-insensitive core oscillator coupled to a specific adaptive temperature signaling pathway.