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10.1155/2015/562580

http://scihub22266oqcxt.onion/10.1155/2015/562580
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suck abstract from ncbi


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pmid26633915      Dis+Markers 2015 ; 2015 (ä): ä
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  • High Serum Level of ?2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study #MMPMID26633915
  • Trailin AV; Pleten MV; Ostapenko TI; Iefimenko NF; Nikonenko OS
  • Dis Markers 2015[]; 2015 (ä): ä PMID26633915show ga
  • Background. Identification of patients at risk for kidney allograft (KAG) failure beyond the first posttransplant year is an unmet need. We aimed to determine whether serum beta-2-microglobulin (?2MG) in the late posttransplant period could predict a decline in KAG function. Methods. We assessed a value of single measurement of serum ?2MG at one to seventeen years after transplantation in predicting the estimated glomerular filtration rate (eGFR) and the decline in eGFR over a period of two years in 79 recipients of KAG. Results. At baseline serum ?2MG concentration was higher (P = 0.011) in patients with allograft dysfunction: 8.67 ± 2.48?µg/mL versus those with satisfactory graft function: 6.67 ± 2.13?µg/mL. Higher ?2MG independently predicted the lower eGFR, the drop in eGFR by ?25% after one and two years, and the value of negative eGFR slope. When combined with proteinuria and acute rejection, serum ?2MG had excellent power in predicting certain drop in eGFR after one year (AUC = 0.910). In conjunction with posttransplant time serum ?2MG had good accuracy in predicting certain eGFR drop after two years (AUC = 0.821). Conclusions. Elevated serum ?2MG in the late posttransplant period is useful in identifying patients at risk for rapid loss of graft function.
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