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2015 ; 2015
(ä): 562580
Nephropedia Template TP
gab.com Text
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English Wikipedia
High Serum Level of ?2-Microglobulin in Late Posttransplant Period Predicts
Subsequent Decline in Kidney Allograft Function: A Preliminary Study
#MMPMID26633915
Trailin AV
; Pleten MV
; Ostapenko TI
; Iefimenko NF
; Nikonenko OS
Dis Markers
2015[]; 2015
(ä): 562580
PMID26633915
show ga
BACKGROUND: Identification of patients at risk for kidney allograft (KAG) failure
beyond the first posttransplant year is an unmet need. We aimed to determine
whether serum beta-2-microglobulin (?2MG) in the late posttransplant period could
predict a decline in KAG function. METHODS: We assessed a value of single
measurement of serum ?2MG at one to seventeen years after transplantation in
predicting the estimated glomerular filtration rate (eGFR) and the decline in
eGFR over a period of two years in 79 recipients of KAG. RESULTS: At baseline
serum ?2MG concentration was higher (P = 0.011) in patients with allograft
dysfunction: 8.67 ± 2.48?µg/mL versus those with satisfactory graft function:
6.67 ± 2.13?µg/mL. Higher ?2MG independently predicted the lower eGFR, the drop
in eGFR by ?25% after one and two years, and the value of negative eGFR slope.
When combined with proteinuria and acute rejection, serum ?2MG had excellent
power in predicting certain drop in eGFR after one year (AUC = 0.910). In
conjunction with posttransplant time serum ?2MG had good accuracy in predicting
certain eGFR drop after two years (AUC = 0.821). CONCLUSIONS: Elevated serum ?2MG
in the late posttransplant period is useful in identifying patients at risk for
rapid loss of graft function.