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10.1016/j.immuni.2015.10.011 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.10.011 C4654997!4654997 !26572061     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26572061 &cmd=llinks): Failed to open stream: HTTP request failed! 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CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion |pdf=|usr=}}{{26572061 }} gab.com Text CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26572061 #FOAvip Deletion of self-antigen-specific T cells during thymic development provides protection from autoimmunity. However, it is unclear how efficiently this occurs for tissue-restricted self antigens, or how immune tolerance is maintained for self-antigen-specific T cells that routinely escape deletion. Here we show that endogenous CD4+ T cells with specificity for a set of tissue-restricted self antigens were not deleted at all. For pancreatic self antigen, this resulted in an absence of steady-state tolerance, while for the lung and intestine, tolerance was maintained by the enhanced presence of thymically-derived antigen-specific Foxp3+ regulatory T (Treg) cells. Unlike deletional tolerance, Treg cell-mediated tolerance was broken by successive antigen challenges. These findings reveal that for some tissue-restricted self antigens, tolerance relies entirely on nondeletional mechanisms that are less durable than T cell deletion. This might explain why autoimmunity is often tissue-specific, and it offers a rationale for cancer vaccine strategies targeting tissue-restricted tumor antigens. Twit Text FOAVip CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26572061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26572061 #FOAvip English Wikipedia <ref>{{Cite pmid|26572061 }}</ref> CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion #MMPMID26572061 Legoux FP ; Lim JB ; Cauley AW ; Dikiy S ; Ertelt J ; Mariani TJ ; Sparwasser T ; Way SS ; Moon JJ Immunity 2015[Nov]; 43 (5 ): 896-908 PMID26572061 show ga Deletion of self-antigen-specific T cells during thymic development provides protection from autoimmunity. However, it is unclear how efficiently this occurs for tissue-restricted self antigens, or how immune tolerance is maintained for self-antigen-specific T cells that routinely escape deletion. Here we show that endogenous CD4+ T cells with specificity for a set of tissue-restricted self antigens were not deleted at all. For pancreatic self antigen, this resulted in an absence of steady-state tolerance, while for the lung and intestine, tolerance was maintained by the enhanced presence of thymically-derived antigen-specific Foxp3+ regulatory T (Treg) cells. Unlike deletional tolerance, Treg cell-mediated tolerance was broken by successive antigen challenges. These findings reveal that for some tissue-restricted self antigens, tolerance relies entirely on nondeletional mechanisms that are less durable than T cell deletion. This might explain why autoimmunity is often tissue-specific, and it offers a rationale for cancer vaccine strategies targeting tissue-restricted tumor antigens. |Animals [MESH] |Autoantigens/*immunology [MESH] |Autoimmunity/immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cancer Vaccines/immunology [MESH] |Forkhead Transcription Factors/immunology [MESH] |Immune Tolerance/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated b(epmc).pdf DeepDyve Pubget Overpricing