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10.1111/ajt.13382 http://scihub22266oqcxt.onion/10.1111/ajt.13382 C4654979!4654979 !26190648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26190648 &cmd=llinks): Failed to open stream: HTTP request failed! 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Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys |pdf=|usr=}}{{26190648 }} gab.com Text Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26190648 #FOAvip Tolerance of allografts achieved in mice via stable mixed hematopoietic chimerism relies essentially on continuous elimination of developing alloreactive T cells in the thymus (central deletion). Conversely, while only transient mixed chimerism is observed in nonhuman primates and patients, it is sufficient to ensure tolerance of kidney allografts. In this setting, it is likely that tolerance depends on peripheral regulatory mechanisms rather than thymic deletion. This implies that, in primates, upsetting the balance between inflammatory and regulatory alloimmunity could abolish tolerance and trigger the rejection of previously accepted renal allografts. In this study, six monkeys that were treated with a mixed chimerism protocol and had accepted a kidney allograft for periods of 1-10 years after withdrawal of immunosuppression received subcutaneous injections of IL-2 cytokine (0.6-3 × 10(6) IU/m(2) ). This resulted in rapid rejection of previously tolerated renal transplants and was associated with an expansion and reactivation of alloreactive pro-inflammatory memory T cells in the host's lymphoid organs and in the graft. This phenomenon was prevented by anti-CD8 antibody treatment. Finally, this process was reversible in that cessation of IL-2 administration aborted the rejection process and restored normal kidney graft function. Twit Text FOAVip Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26190648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26190648 #FOAvip English Wikipedia <ref>{{Cite pmid|26190648 }}</ref> Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys #MMPMID26190648 Yamada Y ; Nadazdin O ; Boskovic S ; Lee S ; Zorn E ; Smith RN ; Colvin RB ; Madsen JC ; Cosimi AB ; Kawai T ; Benichou G Am J Transplant 2015[Dec]; 15 (12 ): 3055-66 PMID26190648 show ga Tolerance of allografts achieved in mice via stable mixed hematopoietic chimerism relies essentially on continuous elimination of developing alloreactive T cells in the thymus (central deletion). Conversely, while only transient mixed chimerism is observed in nonhuman primates and patients, it is sufficient to ensure tolerance of kidney allografts. In this setting, it is likely that tolerance depends on peripheral regulatory mechanisms rather than thymic deletion. This implies that, in primates, upsetting the balance between inflammatory and regulatory alloimmunity could abolish tolerance and trigger the rejection of previously accepted renal allografts. In this study, six monkeys that were treated with a mixed chimerism protocol and had accepted a kidney allograft for periods of 1-10 years after withdrawal of immunosuppression received subcutaneous injections of IL-2 cytokine (0.6-3 × 10(6) IU/m(2) ). This resulted in rapid rejection of previously tolerated renal transplants and was associated with an expansion and reactivation of alloreactive pro-inflammatory memory T cells in the host's lymphoid organs and in the graft. This phenomenon was prevented by anti-CD8 antibody treatment. Finally, this process was reversible in that cessation of IL-2 administration aborted the rejection process and restored normal kidney graft function. |*Kidney Transplantation [MESH] |*Postoperative Complications [MESH] |Animals [MESH] |Bone Marrow Transplantation [MESH] |Chimerism [MESH] |Glomerular Filtration Rate [MESH] |Graft Rejection/drug therapy/*etiology [MESH] |Graft Survival [MESH] |Injections, Subcutaneous [MESH] |Interleukin-2/*administration & dosage [MESH] |Kidney Failure, Chronic/*surgery [MESH] |Kidney Function Tests [MESH] |Macaca fascicularis [MESH] |Mice [MESH] |Risk Factors [MESH] |Transplantation Chimera/*immunology [MESH] |Transplantation Conditioning [MESH] |Transplantation Tolerance/*immunology [MESH]Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced vi(epmc).pdf DeepDyve Pubget Overpricing