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10.1016/j.immuni.2015.09.009 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.09.009 C4654978!4654978!26522985     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2015 ; 43 (5): 859-69 Nephropedia Template TP {{tp|p=26522985|t=2015. Crossreactive ?? T cell receptors are the predominant targets of thymocyte negative selection |pdf=|usr=}}{{26522985}} gab.com Text Crossreactive T cell receptors are the predominant targets of thymocyte negative selection JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual preselection TCRs to provide a direct assessment of these processes at the clonal level in vivo. We found that 15% of random TCRs induced signaling and directed positive (7.5%) or negative (7.5%) selection, depending on strength of signal, whereas the remaining 85% failed to induce signaling or selection. Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major histocompatibility complex (MHC) haplotypes. In contrast, TCRs that were positively selected or non-selected were minimally crossreactive. Negative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4?CD8?? intraepithelial lymphocytes (iIELs). Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. Twit Text FOAVip Crossreactive T cell receptors are the predominant targets of thymocyte negative selection ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip English Wikipedia <ref>{{Cite pmid|26522985}}</ref> Crossreactive ?? T cell receptors are the predominant targets of thymocyte negative selection #MMPMID26522985 McDonald BD; Bunker JJ; Erickson SA; Oh-Hora M; Bendelac A Immunity 2015[Nov]; 43 (5): 859-69 PMID26522985show ga The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual preselection TCRs to provide a direct assessment of these processes at the clonal level in vivo. We found that 15% of random TCRs induced signaling and directed positive (7.5%) or negative (7.5%) selection, depending on strength of signal, whereas the remaining 85% failed to induce signaling or selection. Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major histocompatibility complex (MHC) haplotypes. In contrast, TCRs that were positively selected or non-selected were minimally crossreactive. Negative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4?CD8?? intraepithelial lymphocytes (iIELs). Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. äCrossreactive ?? T cell receptors are the predominant targets of thymo(epmc).pdf DeepDyve Pubget Overpricing