Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.immuni.2015.09.009 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.09.009 C4654978!4654978 !26522985     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26522985 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2015 ; 43 (5 ): 859-69 Nephropedia Template TP {{tp|p=26522985 |t=2015. Crossreactive ?? T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection |pdf=|usr=}}{{26522985 }} gab.com Text Crossreactive T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual pre-selection TCRs to provide a direct assessment of these processes at the clonal level in vivo. We found that 15% of random TCRs induced signaling and directed positive (7.5%) or negative (7.5%) selection, depending on strength of signal, whereas the remaining 85% failed to induce signaling or selection. Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major histocompatibility complex (MHC) haplotypes. In contrast, TCRs that were positively selected or non-selected were minimally crossreactive. Negative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4(-)CD8?(-) intraepithelial lymphocytes (iIELs). Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. Twit Text FOAVip Crossreactive T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26522985 #FOAvip English Wikipedia <ref>{{Cite pmid|26522985 }}</ref> Crossreactive ?? T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection #MMPMID26522985 McDonald BD ; Bunker JJ ; Erickson SA ; Oh-Hora M ; Bendelac A Immunity 2015[Nov]; 43 (5 ): 859-69 PMID26522985 show ga The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual pre-selection TCRs to provide a direct assessment of these processes at the clonal level in vivo. We found that 15% of random TCRs induced signaling and directed positive (7.5%) or negative (7.5%) selection, depending on strength of signal, whereas the remaining 85% failed to induce signaling or selection. Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major histocompatibility complex (MHC) haplotypes. In contrast, TCRs that were positively selected or non-selected were minimally crossreactive. Negative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4(-)CD8?(-) intraepithelial lymphocytes (iIELs). Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. |Animals [MESH] |Cross Reactions/*immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Major Histocompatibility Complex/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C3H [MESH] |Mice, Inbred C57BL [MESH] |Receptors, Antigen, T-Cell, alpha-beta/*immunology [MESH] |Signal Transduction/immunology [MESH] |T-Lymphocyte Subsets/immunology [MESH]Crossreactive ?? T Cell Receptors Are the Predominant Targets of Thymo(epmc).pdf DeepDyve Pubget Overpricing