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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Environ+Health
2015 ; 14
(ä): 89
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Association between perfluoroalkyl acids and kidney function in a cross-sectional
study of adolescents
#MMPMID26590127
Kataria A
; Trachtman H
; Malaga-Dieguez L
; Trasande L
Environ Health
2015[Nov]; 14
(ä): 89
PMID26590127
show ga
BACKGROUND: Perfluoroalkyl acids are synthetic compounds widely used in
industrial and commercial applications. Laboratory studies suggest that these
persistent and bioaccumulative chemicals produce oxidant stress and damage
glomerular endothelial cells, raising concern regarding the impact of these
compounds on renal function. METHODS: We performed cross-sectional analyses of
data 1960 participants aged 12-19 years of the 2003-2010 National Health and
Nutrition Examination Surveys. PFAA exposure was assessed using levels of
perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA),
perfluorononanoic acid, and perfluorohexane sulfonic acid. Primary study outcomes
were estimated glomerular filtration rate (eGFR) and serum uric acid. RESULTS:
While adjusting for demographics, cotinine, prehypertension, insulin resistance,
body mass index, and hypercholesterolemia, adolescents in the highest PFOA and
PFOS quartile had a lower eGFR, 6.84 mL/min/1.73 m(2) (95% CI: 2.19 to 11.48) and
9.69 mL/min/1.73 m(2) (95 % CI: -4.59 to 14.78), respectively, compared to the
lowest quartile. Highest PFOA and PFOS quartiles were also associated with 0.21
mg/dL (95% CI: 0.056 to 0.37) and 0.19 mg/dL (95% CI: 0.032 to 0.34) increases in
uric acid, respectively. CONCLUSIONS: PFAAs are associated with a reduction in
kidney function and increased uric acid levels in otherwise healthy adolescents.
Reverse causation and residual confounding could explain the results. Our study
results confirm and amplify previous findings, though longitudinal studies
examining prenatal and childhood biomarkers in relationship with robust measures
of childhood renal function are needed.
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