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10.1111/nyas.12960 http://scihub22266oqcxt.onion/10.1111/nyas.12960 C4654700!4654700!26579596     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+N+Y+Acad+Sci 2015 ; 1356 (1): 80-9 Nephropedia Template TP {{tp|p=26579596|t=2015. Central tolerance to self revealed by the autoimmune regulator |pdf=|usr=}}{{26579596}} gab.com Text Central tolerance to self revealed by the autoimmune regulator JO: Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=26579596 #FOAvip The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity. Aire regulates the expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs), which play a critical role in the negative selection of autoreactive T cells and the generation of regulatory T cells. More recently, the role of Aire in the development of mTECs have helped elucidate its ability to present the spectrum of TSAs needed to prevent autoimmunity. Molecular characterization of the functional domains of Aire have revealed multiple binding partners that assist Aire?s function in altering gene transcription and chromatin remodeling. These recent advances have further highlighted the importance of Aire in central tolerance. Twit Text FOAVip Central tolerance to self revealed by the autoimmune regulator ????Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=26579596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26579596 #FOAvip English Wikipedia <ref>{{Cite pmid|26579596}}</ref> Central tolerance to self revealed by the autoimmune regulator #MMPMID26579596 Chan A; Anderson MS Ann N Y Acad Sci 2015[Nov]; 1356 (1): 80-9 PMID26579596show ga The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity. Aire regulates the expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs), which play a critical role in the negative selection of autoreactive T cells and the generation of regulatory T cells. More recently, the role of Aire in the development of mTECs have helped elucidate its ability to present the spectrum of TSAs needed to prevent autoimmunity. Molecular characterization of the functional domains of Aire have revealed multiple binding partners that assist Aire?s function in altering gene transcription and chromatin remodeling. These recent advances have further highlighted the importance of Aire in central tolerance. äCentral tolerance to self revealed by the autoimmune regulator (epmc).pdf DeepDyve Pubget Overpricing