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10.12688/f1000research.7095.1 http://scihub22266oqcxt.onion/10.12688/f1000research.7095.1 C4654457!4654457!26664710     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2015 ; 4 (ä): ä Nephropedia Template TP {{tp|p=26664710|t=2015. Circulating nucleic acids: a new class of physiological mobile genetic elements |pdf=|usr=}}{{26664710}} gab.com Text Circulating nucleic acids: a new class of physiological mobile genetic elements JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26664710 #FOAvip Mobile genetic elements play a major role in shaping biotic genomes and bringing about evolutionary transformations. Herein, a new class of mobile genetic elements is proposed in the form of circulating nucleic acids (CNAs) derived from the billions of cells that die in the body every day due to normal physiology and that act intra-corporeally. A recent study shows that CNAs can freely enter into healthy cells, integrate into their genomes by a unique mechanism and cause damage to their DNA. Being ubiquitous and continuously arising, CNA-induced DNA damage may be the underlying cause of ageing, ageing-related disabilities and the ultimate demise of the organism. Thus, DNA seems to act in the paradoxical roles of both preserver and destroyer of life. This new class of mobile genetic element may be relevant not only to multi-cellular organisms with established circulatory systems, but also to other multi-cellular organisms in which intra-corporeal mobility of nucleic acids may be mediated via the medium of extra-cellular fluid. Twit Text FOAVip Circulating nucleic acids: a new class of physiological mobile genetic elements ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26664710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26664710 #FOAvip English Wikipedia <ref>{{Cite pmid|26664710}}</ref> Circulating nucleic acids: a new class of physiological mobile genetic elements #MMPMID26664710 Mittra I F1000Res 2015[]; 4 (ä): ä PMID26664710show ga Mobile genetic elements play a major role in shaping biotic genomes and bringing about evolutionary transformations. Herein, a new class of mobile genetic elements is proposed in the form of circulating nucleic acids (CNAs) derived from the billions of cells that die in the body every day due to normal physiology and that act intra-corporeally. A recent study shows that CNAs can freely enter into healthy cells, integrate into their genomes by a unique mechanism and cause damage to their DNA. Being ubiquitous and continuously arising, CNA-induced DNA damage may be the underlying cause of ageing, ageing-related disabilities and the ultimate demise of the organism. Thus, DNA seems to act in the paradoxical roles of both preserver and destroyer of life. This new class of mobile genetic element may be relevant not only to multi-cellular organisms with established circulatory systems, but also to other multi-cellular organisms in which intra-corporeal mobility of nucleic acids may be mediated via the medium of extra-cellular fluid. äCirculating nucleic acids: a new class of physiological mobile genetic(epmc).pdf DeepDyve Pubget Overpricing