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10.1038/cmi.2014.58

http://scihub22266oqcxt.onion/10.1038/cmi.2014.58
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C4654374!4654374!25088225
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suck abstract from ncbi


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pmid25088225      Cell+Mol+Immunol 2015 ; 12 (1): 31-9
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  • IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation #MMPMID25088225
  • Deng XM; Yan SX; Wei W
  • Cell Mol Immunol 2015[Jan]; 12 (1): 31-9 PMID25088225show ga
  • Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.
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