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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Mol+Immunol 2015 ; 12 (1): 31-9 Nephropedia Template TP
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IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation #MMPMID25088225
Deng XM; Yan SX; Wei W
Cell Mol Immunol 2015[Jan]; 12 (1): 31-9 PMID25088225show ga
Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.