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10.1038/cmi.2014.33 http://scihub22266oqcxt.onion/10.1038/cmi.2014.33 C4654369!4654369 !24813229     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24813229 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Immunol 2015 ; 12 (1 ): 107-12 Nephropedia Template TP {{tp|p=24813229 |t=2015. The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation |pdf=|usr=}}{{24813229 }} gab.com Text The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24813229 #FOAvip Cytokinins are plant hormones that play an integral role in multiple aspects of plant growth and development. The biological functions of cytokinins in mammalian systems are, however, largely uncharacterized. The naturally occurring cytokinin zeatin riboside has recently been demonstrated to activate the mammalian adenosine A(2A) receptor, which is broadly expressed by various cell types including immune system cells, with the activation of the A(2A)R playing a role in the regulation of cells involved in both innate and adaptive immunity. We show for the first time that zeatin riboside modulates mammalian immune system activity via an A(2A)R-dependent mechanism. Specifically, zeatin riboside treatment induces the production of cyclic adenosine monophosphate (cAMP) by T lymphocytes and inhibits the production by CD3(+)CD4(+) T cells of interferon (IFN)-?, IL-2, tumor-necrosis factor (TNF)-?, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-?, IL-2 and TNF-?. Additionally, the upregulation of CD25, CD69 and CD40L by activated T lymphocytes is modulated by zeatin riboside. Zeatin riboside treatment also potently inhibits thioglycollate-induced peritoneal leukocytosis. The immunomodulatory activities of zeatin riboside are blocked by co-treatment with the selective A(2A)R antagonist ZM241385. These data suggest that zeatin riboside possesses therapeutic potential as a mammalian immunomodulatory agent. Twit Text FOAVip The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24813229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24813229 #FOAvip English Wikipedia <ref>{{Cite pmid|24813229 }}</ref> The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation #MMPMID24813229 Lappas CM Cell Mol Immunol 2015[Jan]; 12 (1 ): 107-12 PMID24813229 show ga Cytokinins are plant hormones that play an integral role in multiple aspects of plant growth and development. The biological functions of cytokinins in mammalian systems are, however, largely uncharacterized. The naturally occurring cytokinin zeatin riboside has recently been demonstrated to activate the mammalian adenosine A(2A) receptor, which is broadly expressed by various cell types including immune system cells, with the activation of the A(2A)R playing a role in the regulation of cells involved in both innate and adaptive immunity. We show for the first time that zeatin riboside modulates mammalian immune system activity via an A(2A)R-dependent mechanism. Specifically, zeatin riboside treatment induces the production of cyclic adenosine monophosphate (cAMP) by T lymphocytes and inhibits the production by CD3(+)CD4(+) T cells of interferon (IFN)-?, IL-2, tumor-necrosis factor (TNF)-?, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-?, IL-2 and TNF-?. Additionally, the upregulation of CD25, CD69 and CD40L by activated T lymphocytes is modulated by zeatin riboside. Zeatin riboside treatment also potently inhibits thioglycollate-induced peritoneal leukocytosis. The immunomodulatory activities of zeatin riboside are blocked by co-treatment with the selective A(2A)R antagonist ZM241385. These data suggest that zeatin riboside possesses therapeutic potential as a mammalian immunomodulatory agent. |Animals [MESH] |Antigens, CD/metabolism [MESH] |CD4-Positive T-Lymphocytes/*drug effects/immunology [MESH] |CD8-Positive T-Lymphocytes/*drug effects/immunology [MESH] |Cells, Cultured [MESH] |Cyclic AMP/metabolism [MESH] |Cytokines/metabolism [MESH] |Female [MESH] |Immunomodulation/drug effects [MESH] |Isopentenyladenosine/*analogs & derivatives/pharmacology [MESH] |Leukocytosis/chemically induced/*prevention & control [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Plant Growth Regulators/*pharmacology [MESH] |Receptor, Adenosine A2A/*metabolism [MESH] |Triazines/pharmacology [MESH]The plant hormone zeatin riboside inhibits T lymphocyte activity via a(epmc).pdf DeepDyve Pubget Overpricing