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10.1136/bmjopen-2015-009157 http://scihub22266oqcxt.onion/10.1136/bmjopen-2015-009157 C4654348!4654348!26560063     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26560063&cmd=llinks): Failed to open stream: HTTP request failed! 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Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study |pdf=|usr=}}{{26560063}} gab.com Text Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study JO: BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=26560063 #FOAvip Objective: POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. However, there is no study to investigate whether the extent of decrease in VEGF correlates with clinical outcome. We tested the predictive efficacy of serum VEGF levels in POEMS syndrome. Method: This was an institutional review board approved retrospective observational cohort study of 20 patients with POEMS monitored regularly for more than 12?months (median follow-up, 87?months) after treatment onset using our prospectively accumulated database of POEMS from 1999 to 2015. Patients were treated by autologous peripheral blood stem cell transplantation or thalidomide administration. Serum VEGF was measured by ELISA. Outcome measures included clinical and laboratory findings and relapse-free survival. Results: Serum VEGF levels decreased rapidly after treatment, and stabilised by 6?months post treatment. Patients with normalised serum VEGF levels (<1040?pg/mL) at 6?months showed prolonged relapse-free survival (HR=12.81, 95% CI 2.691 to 90.96; p=0.0001) and greater later clinical improvement. The rate of serum VEGF reduction over the first 6?months post treatment correlated with increased grip strength, serum albumin levels, and compound muscle action potential amplitudes at 12?months. Conclusions: Serum VEGF level at 6?months post treatment is a predicative biomarker for disease activity and prognosis in POEMS syndrome. Serum VEGF could be used as a surrogate endpoint for relapse-free survival or clinical or laboratory improvement of POEMS syndrome for clinical trials. Twit Text FOAVip Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study ????BMJ Open http://www.kidney.de/pget.php?&tw=1&pmid=26560063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26560063 #FOAvip English Wikipedia <ref>{{Cite pmid|26560063}}</ref> Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study #MMPMID26560063 Misawa S; Sato Y; Katayama K; Hanaoka H; Sawai S; Beppu M; Nomura F; Shibuya K; Sekiguchi Y; Iwai Y; Watanabe K; Amino H; Ohwada C; Takeuchi M; Sakaida E; Nakaseko C; Kuwabara S BMJ Open 2015[]; 5 (11): ä PMID26560063show ga Objective: POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. However, there is no study to investigate whether the extent of decrease in VEGF correlates with clinical outcome. We tested the predictive efficacy of serum VEGF levels in POEMS syndrome. Method: This was an institutional review board approved retrospective observational cohort study of 20 patients with POEMS monitored regularly for more than 12?months (median follow-up, 87?months) after treatment onset using our prospectively accumulated database of POEMS from 1999 to 2015. Patients were treated by autologous peripheral blood stem cell transplantation or thalidomide administration. Serum VEGF was measured by ELISA. Outcome measures included clinical and laboratory findings and relapse-free survival. Results: Serum VEGF levels decreased rapidly after treatment, and stabilised by 6?months post treatment. Patients with normalised serum VEGF levels (<1040?pg/mL) at 6?months showed prolonged relapse-free survival (HR=12.81, 95% CI 2.691 to 90.96; p=0.0001) and greater later clinical improvement. The rate of serum VEGF reduction over the first 6?months post treatment correlated with increased grip strength, serum albumin levels, and compound muscle action potential amplitudes at 12?months. Conclusions: Serum VEGF level at 6?months post treatment is a predicative biomarker for disease activity and prognosis in POEMS syndrome. Serum VEGF could be used as a surrogate endpoint for relapse-free survival or clinical or laboratory improvement of POEMS syndrome for clinical trials. äVascular endothelial growth factor as a predictive marker for POEMS sy(epmc).pdf DeepDyve Pubget Overpricing