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10.1038/cmi.2014.56 http://scihub22266oqcxt.onion/10.1038/cmi.2014.56 C4654317!4654317 !25132452     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25132452 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Immunol 2015 ; 12 (3 ): 354-65 Nephropedia Template TP {{tp|p=25132452 |t=2015. A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway |pdf=|usr=}}{{25132452 }} gab.com Text A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25132452 #FOAvip Regulatory T (Treg) cells play a critical role in the maintenance of tolerance. B-1a cells belong to a specific and functionally important B-cell subset that exerts its regulatory role through the production of IL-10. While IL-10 has been correlated with the induction of type 1 Treg (Tr1) cells or Tr1-like cells, whether IL-10-producing B-1a cells are able to induce Treg cells, especially the Tr1 lineage, is poorly understood. We have demonstrated that, similar to the reported B-2 cells, B-1a cells are able to convert naïve CD4(+)CD25(-) T cells into a subset of T cells with suppressive function, which we called 'Treg-of-B1a' cells. Treg-of-B1a cells do not express Foxp3, but upregulate the Treg markers OX40, programmed death 1 (PD-1), inducible costimulator (ICOS) and IL-10R. Moreover, Treg-of-B1a cells do not express Foxp3 and produce high levels of IFN-? and IL-10, but minimal amounts of IL-4; therefore, they resemble Tr1 cells. However, utilizing IL-10(-/-) mice, we showed that IL-10 was not involved in the induction of Treg-of-B1a cells. On the contrary, CD86-mediated costimulation was essential for B-1a cells to drive the induction of Treg-of-B1a cells. Finally, we demonstrated that, in contrast to the Treg cells generated by B-2 cells that mediate contact-dependent suppression, Treg-of-B1a cells suppress through secreting soluble factors. While Tr1 cells mediate suppression mainly through IL-10 or TGF-? secretion, Treg-of-B1a cells mediate suppression through an IL-10- and TGF-?-independent pathway. Together, these findings suggest that B-1a cells induce a functionally and phenotypically distinct Treg population that is dissimilar to the reported Foxp3(+) Treg or Tr1 cells. Twit Text FOAVip A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25132452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25132452 #FOAvip English Wikipedia <ref>{{Cite pmid|25132452 }}</ref> A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway #MMPMID25132452 Hsu LH ; Li KP ; Chu KH ; Chiang BL Cell Mol Immunol 2015[May]; 12 (3 ): 354-65 PMID25132452 show ga Regulatory T (Treg) cells play a critical role in the maintenance of tolerance. B-1a cells belong to a specific and functionally important B-cell subset that exerts its regulatory role through the production of IL-10. While IL-10 has been correlated with the induction of type 1 Treg (Tr1) cells or Tr1-like cells, whether IL-10-producing B-1a cells are able to induce Treg cells, especially the Tr1 lineage, is poorly understood. We have demonstrated that, similar to the reported B-2 cells, B-1a cells are able to convert naïve CD4(+)CD25(-) T cells into a subset of T cells with suppressive function, which we called 'Treg-of-B1a' cells. Treg-of-B1a cells do not express Foxp3, but upregulate the Treg markers OX40, programmed death 1 (PD-1), inducible costimulator (ICOS) and IL-10R. Moreover, Treg-of-B1a cells do not express Foxp3 and produce high levels of IFN-? and IL-10, but minimal amounts of IL-4; therefore, they resemble Tr1 cells. However, utilizing IL-10(-/-) mice, we showed that IL-10 was not involved in the induction of Treg-of-B1a cells. On the contrary, CD86-mediated costimulation was essential for B-1a cells to drive the induction of Treg-of-B1a cells. Finally, we demonstrated that, in contrast to the Treg cells generated by B-2 cells that mediate contact-dependent suppression, Treg-of-B1a cells suppress through secreting soluble factors. While Tr1 cells mediate suppression mainly through IL-10 or TGF-? secretion, Treg-of-B1a cells mediate suppression through an IL-10- and TGF-?-independent pathway. Together, these findings suggest that B-1a cells induce a functionally and phenotypically distinct Treg population that is dissimilar to the reported Foxp3(+) Treg or Tr1 cells. |Animals [MESH] |B-Lymphocyte Subsets/*immunology [MESH] |B-Lymphocytes, Regulatory/*immunology [MESH] |Cell Differentiation [MESH] |Cell Lineage [MESH] |Cytokines/metabolism [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Inducible T-Cell Co-Stimulator Protein/metabolism [MESH] |Intercellular Junctions/immunology [MESH] |Interleukin-10/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH] |Paracrine Communication [MESH] |Programmed Cell Death 1 Receptor/metabolism [MESH] |T-Lymphocyte Subsets/*immunology [MESH]A B-1a cell subset induces Foxp3(-) T cells with regulatory activity t(epmc).pdf DeepDyve Pubget Overpricing