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10.1038/cmi.2014.105

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suck abstract from ncbi


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pmid25418469      Cell+Mol+Immunol 2015 ; 12 (2): 139-53
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  • Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets?but how many arrows in the quiver? #MMPMID25418469
  • Halenius A; Gerke C; Hengel H
  • Cell Mol Immunol 2015[Mar]; 12 (2): 139-53 PMID25418469show ga
  • Major mechanisms for the recognition of pathogens by immune cells have evolved to employ classical and non-classical major histocompatibility complex class I (MHC I) molecules. Classical MHC I molecules present antigenic peptide ligands on infected cells to CD8+ T cells, whereas a key function for non-classical MHC I molecules is to mediate inhibitory or activating stimuli in natural killer (NK) cells. The structural diversity of MHC I puts immense pressure on persisting viruses, including cytomegaloviruses. The very large coding capacity of the human cytomegalovirus allows it to express a whole arsenal of immunoevasive factors assigned to individual MHC class I targets. This review summarizes achievements from more than two decades of intense research on how human cytomegalovirus manipulates MHC I molecules and escapes elimination by the immune system.
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