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10.1002/bies.201400138 http://scihub22266oqcxt.onion/10.1002/bies.201400138 C4654234!4654234 !25400101     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25400101 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25400101 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bioessays 2015 ; 37 (2 ): 148-54 Nephropedia Template TP {{tp|p=25400101 |t=2015. Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences |pdf=|usr=}}{{25400101 }} gab.com Text Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25400101 #FOAvip A gene's "expression profile" denotes the number of transcripts present relative to all other transcripts. The overall rate of transcript production is determined by transcription and RNA processing rates. While the speed of elongating RNA polymerase II has been characterized for many different genes and organisms, gene-architectural features - primarily the number and length of exons and introns - have recently emerged as important regulatory players. Several new studies indicate that rapidly cycling cells constrain gene-architecture toward short genes with a few introns, allowing efficient expression during short cell cycles. In contrast, longer genes with long introns exhibit delayed expression, which can serve as timing mechanisms for patterning processes. These findings indicate that cell cycle constraints drive the evolution of gene-architecture and shape the transcriptome of a given cell type. Furthermore, a tendency for short genes to be evolutionarily young hints at links between cellular constraints and the evolution of animal ontogeny. Twit Text FOAVip Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25400101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25400101 #FOAvip English Wikipedia <ref>{{Cite pmid|25400101 }}</ref> Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences #MMPMID25400101 Heyn P ; Kalinka AT ; Tomancak P ; Neugebauer KM Bioessays 2015[Feb]; 37 (2 ): 148-54 PMID25400101 show ga A gene's "expression profile" denotes the number of transcripts present relative to all other transcripts. The overall rate of transcript production is determined by transcription and RNA processing rates. While the speed of elongating RNA polymerase II has been characterized for many different genes and organisms, gene-architectural features - primarily the number and length of exons and introns - have recently emerged as important regulatory players. Several new studies indicate that rapidly cycling cells constrain gene-architecture toward short genes with a few introns, allowing efficient expression during short cell cycles. In contrast, longer genes with long introns exhibit delayed expression, which can serve as timing mechanisms for patterning processes. These findings indicate that cell cycle constraints drive the evolution of gene-architecture and shape the transcriptome of a given cell type. Furthermore, a tendency for short genes to be evolutionarily young hints at links between cellular constraints and the evolution of animal ontogeny. |Animals [MESH] |Biological Evolution [MESH] |Cell Cycle/genetics/physiology [MESH] |Gene Expression Regulation/genetics/physiology [MESH] |Humans [MESH] |Introns/*genetics [MESH]Introns and gene expression: cellular constraints, transcriptional reg(epmc).pdf DeepDyve Pubget Overpricing