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10.18773/austprescr.2015.028 http://scihub22266oqcxt.onion/10.18773/austprescr.2015.028 C4653963!4653963!26648623     free     free     free       Aust+Prescr 2015 ; 38 (3): 74-8 Nephropedia Template TP {{tp|p=26648623|t=2015. Medical management of malignant melanoma |pdf=|usr=}}{{26648623}} gab.com Text Medical management of malignant melanoma JO: Aust Prescr http://www.kidney.de/pget.php?&tw=1&pmid=26648623 #FOAvip The treatment and outcomes for people with metastatic melanoma have changed considerably in the past few years with the introduction of targeted anticancer drugs.About half of the patients with metastatic melanoma will have activating mutations in the BRAF gene. These people may benefit from a BRAF inhibitor (vemurafenib or dabrafenib) or a MEK inhibitor (trametinib).Addition of a MEK inhibitor to a BRAF inhibitor improves progression-free survival and alters the adverse effect profile.Ipilimumab is another drug indicated for metastatic melanoma. It works by altering the patient?s own immune response to the tumour.Toxicities are common with these drugs and include arthralgias, fatigue, photosensitivity, squamous cell carcinomas, fever, diarrhoea, pruritus and immune-related adverse effects. Twit Text FOAVip Medical management of malignant melanoma ????Aust Prescr http://www.kidney.de/pget.php?&tw=1&pmid=26648623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26648623 #FOAvip English Wikipedia <ref>{{Cite pmid|26648623}}</ref> Medical management of malignant melanoma #MMPMID26648623 Atkinson V Aust Prescr 2015[Jun]; 38 (3): 74-8 PMID26648623show ga The treatment and outcomes for people with metastatic melanoma have changed considerably in the past few years with the introduction of targeted anticancer drugs.About half of the patients with metastatic melanoma will have activating mutations in the BRAF gene. These people may benefit from a BRAF inhibitor (vemurafenib or dabrafenib) or a MEK inhibitor (trametinib).Addition of a MEK inhibitor to a BRAF inhibitor improves progression-free survival and alters the adverse effect profile.Ipilimumab is another drug indicated for metastatic melanoma. It works by altering the patient?s own immune response to the tumour.Toxicities are common with these drugs and include arthralgias, fatigue, photosensitivity, squamous cell carcinomas, fever, diarrhoea, pruritus and immune-related adverse effects. äMedical management of malignant melanoma (epmc).pdf DeepDyve Pubget Overpricing