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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2015 ; 290 (47): 28575-83 Nephropedia Template TP
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Promoter Escape with Bacterial Two-component ? Factor Suggests Retention of ? Region Two in the Elongation Complex* #MMPMID26400263
Sengupta S; Prajapati RK; Mukhopadhyay J
J Biol Chem 2015[Nov]; 290 (47): 28575-83 PMID26400263show ga
Background: The proposed model for promoter escape predicts the destabilization of interactions of ? region 4 with RNA polymerase and DNA.Results: Using a two-component ? factor, we show that YvrI, mimicking the ? region 4, is released, whereas YvrHa, mimicking ? region 2, is retained after promoter escape.Conclusion: This study validates the proposed mechanism for promoter escape.Significance: This study suggests the possibility of certain ?-factors to be retained in elongation complex.