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10.1074/jbc.M115.666008

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C4653711!4653711!26400263
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suck abstract from ncbi


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pmid26400263      J+Biol+Chem 2015 ; 290 (47): 28575-83
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  • Promoter Escape with Bacterial Two-component ? Factor Suggests Retention of ? Region Two in the Elongation Complex* #MMPMID26400263
  • Sengupta S; Prajapati RK; Mukhopadhyay J
  • J Biol Chem 2015[Nov]; 290 (47): 28575-83 PMID26400263show ga
  • Background: The proposed model for promoter escape predicts the destabilization of interactions of ? region 4 with RNA polymerase and DNA.Results: Using a two-component ? factor, we show that YvrI, mimicking the ? region 4, is released, whereas YvrHa, mimicking ? region 2, is retained after promoter escape.Conclusion: This study validates the proposed mechanism for promoter escape.Significance: This study suggests the possibility of certain ?-factors to be retained in elongation complex.
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