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10.1074/jbc.M115.666008 http://scihub22266oqcxt.onion/10.1074/jbc.M115.666008 C4653711!4653711 !26400263     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26400263 &cmd=llinks): Failed to open stream: HTTP request failed! 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Promoter Escape with Bacterial Two-component ? Factor Suggests Retention of ? Region Two in the Elongation Complex |pdf=|usr=}}{{26400263 }} gab.com Text Promoter Escape with Bacterial Two-component Factor Suggests Retention of Region Two in the Elongation Complex JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26400263 #FOAvip The transition from the formation of the RNA polymerase (RNAP)-promoter open complex step to the productive elongation complex step involves "promoter escape" of RNAP. From the structure of RNAP, a promoter escape model has been proposed that suggests that the interactions between ?R4 and RNAP and ?R4 and DNA are destabilized upon transition to elongation. This accounts for the reduced affinity of ? to RNAP and stochastic release of ?. However, as the loss of interaction of ?R4 with RNAP results in the release of intact ?, assessing this interaction remains challenging to be experimentally verified. Here we study the promoter escape model using a two-component ? factor YvrI and YvrHa from Bacillus subtilis that independently contributes to the functions of ?R4 and ?R2 in a RNAP-promoter complex. Our results show that YvrI, which mimics ?R4, is released gradually as transcription elongation proceeds, whereas YvrHa, which mimics ?R2 is retained throughout the elongation complexes. Thus our result validates the proposed model for promoter escape and also suggests that promoter escape involves little or no change in the interaction of ?R2 with RNAP. Twit Text FOAVip Promoter Escape with Bacterial Two-component Factor Suggests Retention of Region Two in the Elongation Complex ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26400263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26400263 #FOAvip English Wikipedia <ref>{{Cite pmid|26400263 }}</ref> Promoter Escape with Bacterial Two-component ? Factor Suggests Retention of ? Region Two in the Elongation Complex #MMPMID26400263 Sengupta S ; Prajapati RK ; Mukhopadhyay J J Biol Chem 2015[Nov]; 290 (47 ): 28575-28583 PMID26400263 show ga The transition from the formation of the RNA polymerase (RNAP)-promoter open complex step to the productive elongation complex step involves "promoter escape" of RNAP. From the structure of RNAP, a promoter escape model has been proposed that suggests that the interactions between ?R4 and RNAP and ?R4 and DNA are destabilized upon transition to elongation. This accounts for the reduced affinity of ? to RNAP and stochastic release of ?. However, as the loss of interaction of ?R4 with RNAP results in the release of intact ?, assessing this interaction remains challenging to be experimentally verified. Here we study the promoter escape model using a two-component ? factor YvrI and YvrHa from Bacillus subtilis that independently contributes to the functions of ?R4 and ?R2 in a RNAP-promoter complex. Our results show that YvrI, which mimics ?R4, is released gradually as transcription elongation proceeds, whereas YvrHa, which mimics ?R2 is retained throughout the elongation complexes. Thus our result validates the proposed model for promoter escape and also suggests that promoter escape involves little or no change in the interaction of ?R2 with RNAP. |*Promoter Regions, Genetic [MESH] |Bacillus subtilis/*metabolism [MESH] |Bacterial Proteins/*metabolism [MESH] |DNA, Bacterial/genetics/metabolism [MESH]Promoter Escape with Bacterial Two-component ? Factor Suggests Retenti(epmc).pdf DeepDyve Pubget Overpricing