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10.1074/jbc.M114.634311

http://scihub22266oqcxt.onion/10.1074/jbc.M114.634311
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C4653703!4653703!26432637
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suck abstract from ncbi


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pmid26432637      J+Biol+Chem 2015 ; 290 (47): 28465-76
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  • Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor ?-1 Activation Mechanism* #MMPMID26432637
  • Gjaltema RAF; de Rond S; Rots MG; Bank RA
  • J Biol Chem 2015[Nov]; 290 (47): 28465-76 PMID26432637show ga
  • Background: PLOD2 expression and subsequent collagen pyridinoline cross-links are induced in fibrotic tissues by TGF?1.Results: TGF?1 induces changes to histone modifications. SP1 and SMAD3 but not P300/CBP are responsible for PLOD2 induction.Conclusion: SMAD3 regulates TGF?1-induced PLOD2 expression via histone-modifying enzymes other than the currently known downstream effectors.Significance: Unraveling PLOD2 transcriptional regulation would provide new ways to interfere in fibrotic processes.
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