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10.1074/jbc.M114.634311 http://scihub22266oqcxt.onion/10.1074/jbc.M114.634311 C4653703!4653703 !26432637     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26432637 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (47 ): 28465-28476 Nephropedia Template TP {{tp|p=26432637 |t=2015. Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor ?-1 Activation Mechanism |pdf=|usr=}}{{26432637 }} gab.com Text Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor -1 Activation Mechanism JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26432637 #FOAvip PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides and is essential for collagen pyridinoline cross-link formation. PLOD2 expression and subsequent pyridinoline cross-links are increased in fibrotic pathologies by transforming growth factor ?-1 (TGF?1). In this report we examined the molecular processes underlying TGF?1-induced PLOD2 expression. We found that binding of the TGF?1 pathway related transcription factors SMAD3 and SP1-mediated TGF?1 enhanced PLOD2 expression and could be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter. Interestingly, the classical co-activators of SMAD3 complexes, p300 and CBP, were not responsible for the enhanced H3 and H4 acetylation. Depletion of SMAD3 reduced PLOD2 acetylated H3 and H4, indicating that another as of yet unidentified histone acetyltransferase binds to SMAD3 at PLOD2. Assessing histone methylation marks at the PLOD2 promoter depicted an increase of the active histone mark H3K79me2, a decrease of the repressive H4K20me3 mark, but no role for the generally strong transcription-related modifications: H3K4me3, H3K9me3 and H3K27me3. Collectively, our findings reveal that TGF?1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGF?1 downstream co-activators and epigenetic modifications. This also suggests that additional activation strategies are used downstream of the TGF?1 pathway, and hence their unraveling could be of great importance to fully understand TGF?1 activation of genes. Twit Text FOAVip Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor -1 Activation Mechanism ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26432637 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26432637 #FOAvip English Wikipedia <ref>{{Cite pmid|26432637 }}</ref> Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor ?-1 Activation Mechanism #MMPMID26432637 Gjaltema RAF ; de Rond S ; Rots MG ; Bank RA J Biol Chem 2015[Nov]; 290 (47 ): 28465-28476 PMID26432637 show ga PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides and is essential for collagen pyridinoline cross-link formation. PLOD2 expression and subsequent pyridinoline cross-links are increased in fibrotic pathologies by transforming growth factor ?-1 (TGF?1). In this report we examined the molecular processes underlying TGF?1-induced PLOD2 expression. We found that binding of the TGF?1 pathway related transcription factors SMAD3 and SP1-mediated TGF?1 enhanced PLOD2 expression and could be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter. Interestingly, the classical co-activators of SMAD3 complexes, p300 and CBP, were not responsible for the enhanced H3 and H4 acetylation. Depletion of SMAD3 reduced PLOD2 acetylated H3 and H4, indicating that another as of yet unidentified histone acetyltransferase binds to SMAD3 at PLOD2. Assessing histone methylation marks at the PLOD2 promoter depicted an increase of the active histone mark H3K79me2, a decrease of the repressive H4K20me3 mark, but no role for the generally strong transcription-related modifications: H3K4me3, H3K9me3 and H3K27me3. Collectively, our findings reveal that TGF?1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGF?1 downstream co-activators and epigenetic modifications. This also suggests that additional activation strategies are used downstream of the TGF?1 pathway, and hence their unraveling could be of great importance to fully understand TGF?1 activation of genes. |Acetylation [MESH] |Cells, Cultured [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/metabolism [MESH] |Smad3 Protein/metabolism [MESH] |Sp1 Transcription Factor/metabolism [MESH]Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternat(epmc).pdf DeepDyve Pubget Overpricing