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10.1074/jbc.M115.670901 http://scihub22266oqcxt.onion/10.1074/jbc.M115.670901 C4653699!4653699!26442586     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (47): 28428-37 Nephropedia Template TP {{tp|p=26442586|t=2015. Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders* |pdf=|usr=}}{{26442586}} gab.com Text Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26442586 #FOAvip Background: 20 read-through mutations that produce C-terminally extended proteins are related to human hereditary disorders.Results: The C-terminal extended proteins of mouse cFLIP-L (cellular FLICE-like apoptosisinhibitory protein) and human PNPO (pyridoxamine 5-phosphate oxidase) and HSD3B2 (3-hydroxysteroid dehydrogenase type II) are ubiquitylated and degraded, involving an E3 ligase, TRIM21, for cFLIP-L and PNPO degradation.Conclusion: Read-through mutant cFLIP-L, PNPO, and HSD3B2 are degraded by the ubiquitin-proteasome system.Significance: Degradation of read-through mutant proteins may cause hereditary disorders. Twit Text FOAVip Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26442586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26442586 #FOAvip English Wikipedia <ref>{{Cite pmid|26442586}}</ref> Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders* #MMPMID26442586 Shibata N; Ohoka N; Sugaki Y; Onodera C; Inoue M; Sakuraba Y; Takakura D; Hashii N; Kawasaki N; Gondo Y; Naito M J Biol Chem 2015[Nov]; 290 (47): 28428-37 PMID26442586show ga Background: 20 read-through mutations that produce C-terminally extended proteins are related to human hereditary disorders.Results: The C-terminal extended proteins of mouse cFLIP-L (cellular FLICE-like apoptosisinhibitory protein) and human PNPO (pyridoxamine 5-phosphate oxidase) and HSD3B2 (3-hydroxysteroid dehydrogenase type II) are ubiquitylated and degraded, involving an E3 ligase, TRIM21, for cFLIP-L and PNPO degradation.Conclusion: Read-through mutant cFLIP-L, PNPO, and HSD3B2 are degraded by the ubiquitin-proteasome system.Significance: Degradation of read-through mutant proteins may cause hereditary disorders. äDegradation of Stop Codon Read-through Mutant Proteins via the Ubiquit(epmc).pdf DeepDyve Pubget Overpricing