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10.1074/jbc.M115.682385

http://scihub22266oqcxt.onion/10.1074/jbc.M115.682385
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C4653686!4653686!26438826
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suck abstract from ncbi


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pmid26438826      J+Biol+Chem 2015 ; 290 (47): 28311-20
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  • High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1* #MMPMID26438826
  • Suarez S; McCollum GW; Jayagopal A; Penn JS
  • J Biol Chem 2015[Nov]; 290 (47): 28311-20 PMID26438826show ga
  • Background: Pericyte cell death occurs early in diabetic retinopathy, but the cause remains unknown.Results: High glucose-induced retinal pericyte apoptosis is mediated, in part, by the association of GAPDH and Siah1.Conclusion: Inhibition of the GAPDH/Siah1 pro-apoptotic pathway inhibits high glucose-induced human pericyte death.Significance: Understanding the mechanism of diabetes-induced pericyte apoptosis could direct development of new therapeutic strategies for early diabetic retinopathy.
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