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10.1074/jbc.M115.668855

http://scihub22266oqcxt.onion/10.1074/jbc.M115.668855
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C4653683!4653683!26405038
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suck abstract from ncbi


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pmid26405038      J+Biol+Chem 2015 ; 290 (47): 28272-85
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  • Cell Polarity Kinase MST4 Cooperates with cAMP-dependent Kinase to Orchestrate Histamine-stimulated Acid Secretion in Gastric Parietal Cells* #MMPMID26405038
  • Jiang H; Wang W; Zhang Y; Yao WW; Jiang J; Qin B; Yao WY; Liu F; Wu H; Ward TL; Chen CW; Liu L; Ding X; Liu X; Yao X
  • J Biol Chem 2015[Nov]; 290 (47): 28272-85 PMID26405038show ga
  • Background: Polarized acid secretion in gastric parietal cells requires ezrin and its phosphorylation at Ser-66 by cAMP-dependent protein kinase (PKA).Results: Phosphorylation of Ser-66 induces an ezrin conformational change that promotes the phosphorylation of Thr-567 by MST4.Conclusion: PKA phosphorylates MST4 and ezrin to orchestrate histamine-elicited acid secretion.Significance: The PKA-MST4-ezrin signaling axis is essential for parietal cell activation.
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