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10.1074/jbc.M115.673806

http://scihub22266oqcxt.onion/10.1074/jbc.M115.673806
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C4653681!4653681!26446795
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suck abstract from ncbi


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pmid26446795      J+Biol+Chem 2015 ; 290 (47): 28245-56
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  • The Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE Complexes* #MMPMID26446795
  • Dubuke ML; Maniatis S; Shaffer SA; Munson M
  • J Biol Chem 2015[Nov]; 290 (47): 28245-56 PMID26446795show ga
  • Background: Sec6 has been reported to inhibit SNARE complex assembly, in contrast to other tethering complexes.Results: Sec6 does not inhibit SNARE assembly. Rather, it binds assembled SNARE complexes. Disrupting this interaction results in growth defects in yeast.Conclusion: This interaction is important for a functional exocytic pathway.Significance: The exocyst is likely to have mechanisms of SNARE regulation comparable with other multisubunit tethering complexes.
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