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10.1074/jbc.M115.655597

http://scihub22266oqcxt.onion/10.1074/jbc.M115.655597
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C4653678!4653678!26442585
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suck abstract from ncbi


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pmid26442585      J+Biol+Chem 2015 ; 290 (47): 28200-13
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  • A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor* #MMPMID26442585
  • Wang Y; Zheng Z; Zhang J; Wang Y; Kong R; Liu J; Zhang Y; Deng H; Du X; Ke Y
  • J Biol Chem 2015[Nov]; 290 (47): 28200-13 PMID26442585show ga
  • Background: Retinoblastoma protein (RB) is frequently targeted for proteasomal degradation by oncoproteins.Results: NRBE3 promotes RB degradation as an E3 and is transcriptionally activated by E2F1.Conclusion: NRBE3 is an E3 ubiquitin ligase for RB and regulates the cell cycle.Significance: This study identified a novel E3 ubiquitin ligase for RB that might be a potential oncoprotein in human cancers.
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