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10.1038/srep16849 http://scihub22266oqcxt.onion/10.1038/srep16849 C4653646!4653646!26585410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26585410&cmd=llinks): Failed to open stream: HTTP request failed! 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Dexmedetomidine Inhibits TLR4/NF-?B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats |pdf=|usr=}}{{26585410}} gab.com Text Dexmedetomidine Inhibits TLR4/NF- B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26585410 #FOAvip Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-?B(NF-?B) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-induced AKI is associated with inflammatory response, and to assess the effects of dexmedetomidine pretreatment on kidneys in rats following orthotopic autologous liver transplantation(OALT). Seventy-seven adult male rats were randomized into 11 groups. Kidney tissue histopathology and levels of blood urea nitrogen(BUN) and serum creatinine(SCr) were evaluated. Levels of TLR4, NF-?B, tumor necrosis factor-?, and interleukin-1? levels were measured in kidney tissues. OALT resulted in significant kidney functional impairment and tissue injury. Pre-treatment with dexmedetomidine decreased BUN and SCr levels and reduced kidney pathological injury, TLR4 expression, translocation of NF-?B, and cytokine production. The effects of dexmedetomidine were reversed by pre-treatment with atipamezole and BRL44408, but not ARC239. These results were confirmed by using ?2A-adrenergic receptor siRNA which reversed the protective effect of dexmedetomidine on attenuating NRK-52E cells injury induced by hypoxia reoxygenation. In conclusion, Dexmedetomidine-pretreatment attenuates OALT-induced AKI in rats which may be contributable to its inhibition of TLR4/MyD88/NF-?B pathway activation. The renoprotective effects are related to ?2A-adrenergic receptor subtypes. Twit Text FOAVip Dexmedetomidine Inhibits TLR4/NF- B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26585410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26585410 #FOAvip English Wikipedia <ref>{{Cite pmid|26585410}}</ref> Dexmedetomidine Inhibits TLR4/NF-?B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats #MMPMID26585410 Yao H; Chi X; Jin Y; Wang Y; Huang P; Wu S; Xia Z; Cai J Sci Rep 2015[]; 5 (ä): ä PMID26585410show ga Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-?B(NF-?B) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-induced AKI is associated with inflammatory response, and to assess the effects of dexmedetomidine pretreatment on kidneys in rats following orthotopic autologous liver transplantation(OALT). Seventy-seven adult male rats were randomized into 11 groups. Kidney tissue histopathology and levels of blood urea nitrogen(BUN) and serum creatinine(SCr) were evaluated. Levels of TLR4, NF-?B, tumor necrosis factor-?, and interleukin-1? levels were measured in kidney tissues. OALT resulted in significant kidney functional impairment and tissue injury. Pre-treatment with dexmedetomidine decreased BUN and SCr levels and reduced kidney pathological injury, TLR4 expression, translocation of NF-?B, and cytokine production. The effects of dexmedetomidine were reversed by pre-treatment with atipamezole and BRL44408, but not ARC239. These results were confirmed by using ?2A-adrenergic receptor siRNA which reversed the protective effect of dexmedetomidine on attenuating NRK-52E cells injury induced by hypoxia reoxygenation. In conclusion, Dexmedetomidine-pretreatment attenuates OALT-induced AKI in rats which may be contributable to its inhibition of TLR4/MyD88/NF-?B pathway activation. The renoprotective effects are related to ?2A-adrenergic receptor subtypes. äDexmedetomidine Inhibits TLR4/NF-?B Activation and Reduces Acute Kidne(epmc).pdf DeepDyve Pubget Overpricing