Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1507052112 http://scihub22266oqcxt.onion/10.1073/pnas.1507052112 C4653170!4653170!26512111     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (45): E6195-204 Nephropedia Template TP {{tp|p=26512111|t=2015. RNA sensing by conventional dendritic cells is central to the development of lupus nephritis |pdf=|usr=}}{{26512111}} gab.com Text RNA sensing by conventional dendritic cells is central to the development of lupus nephritis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26512111 #FOAvip Systemic lupus erythematosus is a complex autoimmune disease where genetic and environmental factors play equally important roles. Recent research has identified that upregulation of the innate immune Toll-like receptor 7 (TLR7) is fundamental for the development of severe disease. In our Sle1Tg7 model system, we show that increased expression of TLR7 in dendritic cells (DCs) is important for the development of kidney disease. Furthermore, we identify conventional CD11b+ DCs infiltrating the glomeruli of diseased mice. In a resting state, human myeloid DCs express negligible levels of TLR7. However, exposure to multiple stimuli results in a dramatic increase in expression. Together, these findings suggest a role for myeloid DC-TLR7 in clinical disease and that TLR7 expression in this cellular compartment may represent a novel target for therapeutic investigation. Twit Text FOAVip RNA sensing by conventional dendritic cells is central to the development of lupus nephritis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26512111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26512111 #FOAvip English Wikipedia <ref>{{Cite pmid|26512111}}</ref> RNA sensing by conventional dendritic cells is central to the development of lupus nephritis #MMPMID26512111 Celhar T; Hopkins R; Thornhill SI; De Magalhaes R; Hwang SH; Lee HY; Yasuga H; Jones LA; Casco J; Lee B; Thamboo TP; Zhou XJ; Poidinger M; Connolly JE; Wakeland EK; Fairhurst AM Proc Natl Acad Sci U S A 2015[Nov]; 112 (45): E6195-204 PMID26512111show ga Systemic lupus erythematosus is a complex autoimmune disease where genetic and environmental factors play equally important roles. Recent research has identified that upregulation of the innate immune Toll-like receptor 7 (TLR7) is fundamental for the development of severe disease. In our Sle1Tg7 model system, we show that increased expression of TLR7 in dendritic cells (DCs) is important for the development of kidney disease. Furthermore, we identify conventional CD11b+ DCs infiltrating the glomeruli of diseased mice. In a resting state, human myeloid DCs express negligible levels of TLR7. However, exposure to multiple stimuli results in a dramatic increase in expression. Together, these findings suggest a role for myeloid DC-TLR7 in clinical disease and that TLR7 expression in this cellular compartment may represent a novel target for therapeutic investigation. äRNA sensing by conventional dendritic cells is central to the developm(epmc).pdf DeepDyve Pubget Overpricing